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3471 J. Cosmet. Sci., 72, 1–15 (July/August 2021)2021) Choline Proline Ionic Liquid-Functionalized Fe 3 O 4 @SiO 2 Nanoparticle Magnetic Solid Phase Extraction Coupled with High-Performance Liquid Chromatography for Analysis of Allura Red in Lipstick Sample QI LI, QING GAO, WEI LIU, and XIASHI ZHU , College of Guangling, Yangzhou University, Yangzhou University, Yangzhou 225002, PR China (X.Z.) College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou University, Yangzhou 225002, PR China (Q.L., Q.G., W.L., X.Z.) Accepted for publication April 2, 2021. Synopsis A separation/analysis of allura red based on magnetic solid-phase extraction–high-performance liquid chromatography was developed. The extractant was prepared by functionalizing choline proline ionic liquid on Fe3O4@SiO2(Fe3O4@SiO2@[Ch][Pro]). Infl uences of experimental variables including extraction condition (material amount, pH, time, temperature, ionic strength, and sample volume) and elution conditions (eluent selection, amount, time) were evaluated. Under the optimal conditions, good linear calibration curves were obtained in the range of 0.02–5.0 μg/mL, and limits of detection was 9.0 ng/mL. The proposed method was successfully applied for the determination of allura red in lipstick sample. I NTRODUCTION Dyes are often used as colorants in foods, medicines, and cosmetics. Cosmetics have been widely welcomed by consumers in recent years. Lipsticks can change the lip color this intuitive feeling is more attractive to consumers (1). Allura red is a dye commonly used in lipsticks as a synthetic sulfonated azo red dye (Figure 1), compared with natu- ral pigments, it has the advantages of good stability and low cost, but the molecular structure contains an azo group (-N = N-), which may cause adverse effects on human health (2). And the dye in lipstick is easy to be eaten by consumers, and excessive in- take of allura red can cause carcinogenic diseases, allergies, multiple sclerosis, and brain damage (3). Therefore, it is necessary to determine the allura red of lipstick. At present, the commonly used methods for determining allura red are UV spectrophotometry (2) Address all correspondence to Xiashi Zhu at xszhu@yzu.edu.cn or zhuxiashi@sina.com. 347–361