418 J. Cosmet. Sci., 72, 418–431 (July/August 2021) Comparative Efficacy of 35% Glycolic Acid Peel vs. ­ Jessner Peel as an Adjuvant to Topical Triple Combination (2% Hydroquinone, 0.025% Tretinoin, 0.01% Fluocinolone Acetonide) Therapy in Melasma Females Cases AVANI MODI, SWETA PARMAR, and YOGESH MARFATIYA Gmers Medical College, Vadnagar, Gujarat, India (A.M., S.P.), Department of Skin and V.D., Gmers Medical College, Vadnagar 384355, Gujarat, India Department of Skin & V.D., Medical College and S.S.G. Hospital Vadodara 390001, Gujarat, India Accepted for publication June 30, 2021. Synopsis Melasma is a common, acquired, circumscribed hypermelanosis of sun-exposed skin. It presents as symmetric, hyperpigmented macules having irregular, serrated, and geographic borders. Compare the efficacy of 35% gycolic acid (GA) peel vs. Jessner peel (JP) as an adjuvant to topical triple combination (2% Hydroquinone, 0.025% tretinoin, 0.01% Fluocinolone acetonide) therapy in Melasma in females. Sixty cases of Melasma attending Skin- VD OPD, Baroda Medical College from September 1, 2016 to July 30,/2017 were enrolled. Among them, 12% cases had history of menstrual irregularity, 5% cases had past history of oral contraceptive (OC) pill intake, and 10% cases had history of working outdoors. Most common pattern of melasma was centrofacial 32 cases (53%) which was followed by malar pattern in 27 cases (47%) and mandibular pattern in one case (2%). Fifty cases who completed study were evaluated for comparative efficacy of GA peel versus JP as an adjuvant to topical triple combination therapy. Average reduction in Melasma Area and Severity Index (MASI) score in cases treated with GA peel group was 58.56% with Jessner peel group was 59.12%. In GA peel group, 84% cases had moderate to good improvement, whereas in JP group 92% cases had moderate to good improvement. According to present study, safety and efficacy profile of 35% GA peel vs. JP was almost same. Both can be used as an adjuvant to topical triple combination therapy of 2% hydroquinone, 0.025% tretinoin, and 0.01% fluocinolone acetonide in females suffering from melasma. We recommend that it will be safer for the pregnant women to get the GA peel rather than the treatment containing hydroquinone and tretinoin since the activity/performance is very similar. INTRODUCTION Melasma is an acquired, circumscribed, pigmentary disorder characterized by more or less symmetrically distributed and medium to dark brown macules with defined geographic Address all correspondence to Sweta Parmar at drswetaparmar@gmail.com