423 COMPARATIVE EFFICACY OF 35% GLYCOLIC ACID PEEL In the present study, the most common pattern of melasma was centrofacial, in 32 cases (53%), which was followed by malar pattern, in 27 cases (47%), and mandibular pattern, in one case (2%). (Table IV) According to Sanchez N.P. et al., centrofacial pattern is the most common pattern (affect- ing 63% of all cases) followed by malar pattern (21%) and mandibular pattern (16%) (7). • Fifty melasma cases completed the study (14 weeks) were evaluated for com- parative efficacy and adverse cutaneous side effect of GA peel versus JP as an adjuvant to topical triple combination therapy. Table VII Pre- and Posttreatment MASI Score (B) Jessner Peel Group (n = 25) No. MASI Score Improvement in Percentage (%) Baseline 6 week 14 week Difference 1 13.2 10.2 4.4 8.8 66 2 22.5 17.4 11.1 11.4 51 3 20.1 18.2 16.8 3.3 16 4 13.9 10.8 6.4 7.5 54 5 16.8 9.7 6.8 10 60 6 21 7.6 5.1 15.9 76 7 10.9 7.6 3.7 7.2 66 8 11.7 5.6 4.8 6.9 59 9 16.8 10.8 9.7 7.1 42 10 7.6 5 2.7 4.9 64 11 12.6 10.8 6 6.6 52 12 18.5 17.2 5 13.5 73 13 10 4.4 3.9 6.1 61 14 15.6 10.8 5.1 10.5 67 15 25 12.2 10 15 60 16 7.9 5.6 3.7 4.2 53 17 20.2 17.3 8.5 11.7 58 18 19.4 10.8 8.3 11.1 57 19 8 5.1 3.4 4.6 58 20 12 10 4.8 7.2 60 21 8.3 5.6 2.3 6 72 22 15.9 13.8 5.8 10.1 58 23 23.1 18.9 6.8 16.3 71 24 16.8 12.5 8.3 8.5 51 25 14.4 10.2 3.7 10.7 74 MASI: Melasma Area and Severity Index. Table VIII Improvement in MASI Score (%) (n = 50) Improvement GA Peel Group No. of Cases (n = 25) Jessner Peel Group No. of Cases (n = 25) Excellent (90%) — — Good (75–90%) 1 (4%) 1 (4%) Moderate (50–75%) 20 (80%) 22 (88%) Inadequate (50%) 4 2 GA: glycolic acid MASI: Melasma Area and Severity Index.

424 JOURNAL OF COSMETIC SCIENCE In GA peel group, average baseline score was 14.37 after 6 week score was reduced to 12.12 and at the end of treatment (14 weeks), it was further reduced to an average score of 6.32. There was a significant difference between baseline and at the end of treatment MASI score. (Tables V, VI) Statistical analysis: Paired t-test was applied. 1. For baseline and 6 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 2. For baseline and 14 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 (Statistical significance at the level of 95% confidence interval) Average reduction in MASI score in cases with GA peel group = 58.56% (Figures 1, 2, 3, 4) In JP group, the average baseline score was 15.68, after 6 week score was reduced to 8.5, and at the end of treatment (14 week), it was further reduced to average score of 6.28. (Figures 5, 6, 7, 8). There was a significant difference between baseline and at the end of treatment MASI score. (Table VII) Statistical analysis: Paired t-test was applied. • For baseline and 6 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 • For baseline and 14 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 (Statistical significance at the level of 95% confidence interval) Average reduction in MASI score in cases with JP group = 59.12% In GA peel group, 84% cases had moderate to good improvement, whereas in JP group 92% cases had moderate to good improvement. (Table VIII) Table IX Pre- and Posttreatment Average MASI Score: at the 0 Week (i.e. Baseline) and at the 14 Week (i.e. End of Treatment) Peel Group Average MASI score Percentage Improvement (%) Pretreatment Posttreatment Glycolic acid peel (n = 25) 14.37 6.32 58.56 Jessner peel (n = 25) 15.68 6.28 59.12 MASI: Melasma Area and Severity Index. Table X Adverse Cutaneous Side Effects (n = 50) Type of side effects Glycolic acid peel (n = 25) Jessner peel (n = 25) Total Erythema 6 14 20 Burning 4 6 10 Pigmentation 3 2 5 Dry skin 1 2 3