ANTIPERSPIRANT ACTION OF ALUMINUM SALTS 289 Figure 4. The acrosyringium immediately after a 3-hr exposure to 20% AICl• ß 6H•O. An amorphous cast has formed within the intraepidermal portion of the duct exempting the horny layer portion. Below the level of the granular layer the luminal cells are shrunken with pyknotic nuclei. A mild lymphocytic infiltrate surrounds the duct where it enters the epidermis. The latter change is not an intrinisic part of the process, representing sub-clinical miliaria after heat stress (H&E, x 400).

290 .JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS •.' •,ll•.d.. ..• Figure 5. After exposure to 20% A1CI• ß 6H,O for 24 hr,-the intraepidermal portion of the duct contains a solid mass of aluminum-positive material corresponding to the eosinophilic, amorphous cast with the H&E stain (Morin, x400). Our findings establish beyond further doubt that there is a physical obstruction to the passage of sweat. Moreover, we now have sufficient artatomic and physiologic information to fashion a coherent concept of how aluminum chloride, and presumably other aluminum salts induce the anhidrotic state.

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