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]. Cosmet. Sci., 58, 663-666 (November/December 2007) Abstracts International Journal of Cosmetic Science Vol. 29, No. 4, 2007* Contact Angle Measurement - A Reliable Supportive Method For Screening Water-Resistance Of Ultraviolet­ Proceting Products In Vivo R. Hagens, T. Mann, V. Schreiner, H. G. Barlag, H. Wenck, K.-P. Wittem and W. Mei Beiersdorf AG, Research Bioengineering, Unnastra8e 48, D- 20245 Hamburg, Germany Ralf Hagens, Beiersdorf AG, Research Bioengineering, Unnastra8e 48, D-20245 Hamburg, Germany Substantivity of sunscreen formulations is affected by the wash-out rate of ultraviolet-absorber and -reflector compounds in water. Water-resistance of sunscreen formulations is currently determined according to a standardized European Cosmetic Toiletry and Perfumery Association (COLIPA) protocol, encompassing the determination of a minimal erythemal dose before and after a defined immersion step in water. It can be supposed that the higher the wettability of a treated skin area, the higher is the wash-out rate of sunscreen compounds. This present report addresses the validity of determining the wettability of treated skin alone as a measure for the water-resistance of sunscreen products. The report addresses the robustness, accuracy and congruence of a recently developed wettability test, based on the measurement of the contact angle (CA) of a sessile water drop on treated skin areas. Contact angle data of 66 sunscreen formulations are compared with the corresponding results of 81 water-resistance tests, using the sun protection factor (SPF)/immersion/SPF method. Sunscreen products tested by the CA method were applied to the skin of the volar forearm of test subjects at a defined dose and drying-time, using a standardized application and recording device. Contact angles between a sessile water drop and skin were recorded by a Charge-Coupled Device (CCD) camera and subjected to automatic contour analysis. Taking the SPF/immersion/SPF method as gold standard, accuracy parameters of the CA method were determined. By using an appropriate cut-off level of CAs, the CA method has a specificity and positive-predictive value of 100%, and turns out to be a reliable screening method to identify water­ resistant formulations. Based on our findings, those formulations that give CAs above 30° may be categorized water-proof without further testing by the COUP A water­ resistance method. In Vitro human Nail Penetration and Kinetics of Panthenol X. Hf*, S. B. Homby t , R. C. Wester*, S. Barbadillo*, Y. Appa and H. Maibach* *Dermatology, University of California San Francisco, Surge 110, Box 0989, 9 f Medical Center Way, San Francisco, CA 94143 and 'Neutrogena Corp., 5760 West 96ht Street, R&D Building, Los Angeles, CA 90045, U.S.A. Dr Xiaoying Hui, Department of Dermatology, University of California San Francisco, Surge 110, Box 0989, 90 Medical Center Way, San Francisco, CA 94143, U.S.A. The in vitro absorption of panthenol into and through the human nail was examined in this study. Panthenol, the alcohol form of pantothenic acid (vitamin BS), is believed to act as a humectant and improve the flexibility and strength * These abstracts appear as they were originally published. They have not been edited by the Journal of Cosmetic science. 663