314 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS SUMMARY Bacteriostatic and fungistatic data on a number of bis-phenols have been presented and the relationship between chemical structure and anti- microbial activity has been discussed. The standard of reference was hexachlorophene which was not surpassed in bacteriostatic activity against S. aureus and E. co/i, except by one of its isomers, 2,2'-methylenebis (3,4,5- trichlorophenol). The latter compound is distinctly more potent, but its manufacture would be difficult and costly. REFERENCES (1) Gump, W. S., U.S. Patent No. 2,250,480, July 29, 1941. (2) Cade, A. R., Soap Sanit. Chemicals, 20, No. 2, 11 (1944). (3) Gump, W. S., Ibid., 21, No. 3, 36 and No. 4, 50 (1945). (4) Cade, A. R., and Gump, W. S., "The Bis-phenols," chapter 14 in "Antiseptics, Disinfect- ants, Fungicides, and Chemical and Physical Sterilization," edited by George F. Red- dish, 2nd edition, Philadelphia, Lea & Febiger (1957). (53 Marsh, P. B., and Butler, M. L., Ind. Eng. Chem., 38, 701 (1946). (6) Marsh, P. B., Butler, M. L., and Clark, B. S., Ibid., 41, 2176 (1949). (7) Gump, W. S., and Cade, A. R., Soap Sanit. Chemicals, 28, No. 12, 52 (1952). (8) See Finkelstein, J., and Linder, S. M., 5•. Am. Chem. Soc., 71, 1010 (1949) for the prepara- tion of closely related substances. (9) Bechhold, H., and Ehrlich, P., Z. physiol. Chem., 47, 173 (1906). (10) Corey, R. R., and Shirk, H. S., Arch. Biochem. Biophys., 56, 196 (1955). (11) Pfleger, R., Schraufst/itter, E., Gehringer, F., and Sciuk, J., Naturforsch., 4b, 344 (1949). (12) Florestano, H. J., and Bahler, M. E., )t. Am. Pharm. Assoc., Sci. Ed., 42, 576 (1953). (13) Wendel, K., Zentr. Bakteriol. Parasitenk., Abt. II, 110, 45 (1957). (14) Johary, N. S., Guha, S.S., and Guha, P. C., •7. Indian Int. Sci., 34, 287 (1952). (15) Tiessens, G. J., Rec. Tray. Chim., 50, 112 (1931). CHICAGO CHAPTER NEWS DR. MORRIS V. SHEL^NSKI spoke on April 12. The subject was a very timely one in the general category of toxicological testing of cosmetic products. Dr. Shelanski attended Harvard University, 1939-1943, and continued his education in the Faculty of Medicine, McGill University and received degree M.D., C.M., in 1947. His present position is director, Industrial Biology Research and Testing Laboratories, Inc., Philadelphia, Pa. All meetings of the Chicago Chapter are held in Henrici's Restaurant in the Merchandise Mart.

314 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS SUMMARY Bacteriostatic and fungistatic data on a number of bis-phenols have been presented and the relationship between chemical structure and anti- microbial activity has been discussed. The standard of reference was hexachlorophene which was not surpassed in bacteriostatic activity against S. aureus and E. co/i, except by one of its isomers, 2,2'-methylenebis (3,4,5- trichlorophenol). The latter compound is distinctly more potent, but its manufacture would be difficult and costly. REFERENCES (1) Gump, W. S., U.S. Patent No. 2,250,480, July 29, 1941. (2) Cade, A. R., Soap Sanit. Chemicals, 20, No. 2, 11 (1944). (3) Gump, W. S., Ibid., 21, No. 3, 36 and No. 4, 50 (1945). (4) Cade, A. R., and Gump, W. S., "The Bis-phenols," chapter 14 in "Antiseptics, Disinfect- ants, Fungicides, and Chemical and Physical Sterilization," edited by George F. Red- dish, 2nd edition, Philadelphia, Lea & Febiger (1957). (53 Marsh, P. B., and Butler, M. L., Ind. Eng. Chem., 38, 701 (1946). (6) Marsh, P. B., Butler, M. L., and Clark, B. S., Ibid., 41, 2176 (1949). (7) Gump, W. S., and Cade, A. R., Soap Sanit. Chemicals, 28, No. 12, 52 (1952). (8) See Finkelstein, J., and Linder, S. M., 5•. Am. Chem. Soc., 71, 1010 (1949) for the prepara- tion of closely related substances. (9) Bechhold, H., and Ehrlich, P., Z. physiol. Chem., 47, 173 (1906). (10) Corey, R. R., and Shirk, H. S., Arch. Biochem. Biophys., 56, 196 (1955). (11) Pfleger, R., Schraufst/itter, E., Gehringer, F., and Sciuk, J., Naturforsch., 4b, 344 (1949). (12) Florestano, H. J., and Bahler, M. E., )t. Am. Pharm. Assoc., Sci. Ed., 42, 576 (1953). (13) Wendel, K., Zentr. Bakteriol. Parasitenk., Abt. II, 110, 45 (1957). (14) Johary, N. S., Guha, S.S., and Guha, P. C., •7. Indian Int. Sci., 34, 287 (1952). (15) Tiessens, G. J., Rec. Tray. Chim., 50, 112 (1931). CHICAGO CHAPTER NEWS DR. MORRIS V. SHEL^NSKI spoke on April 12. The subject was a very timely one in the general category of toxicological testing of cosmetic products. Dr. Shelanski attended Harvard University, 1939-1943, and continued his education in the Faculty of Medicine, McGill University and received degree M.D., C.M., in 1947. His present position is director, Industrial Biology Research and Testing Laboratories, Inc., Philadelphia, Pa. All meetings of the Chicago Chapter are held in Henrici's Restaurant in the Merchandise Mart.