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J. Soc. Cosmet. Chem., 29, 487-496 (August 1978) Ober die Beeinflussung der anaeroben Bakterienflora im Talgdrfisen- ausffihrtmgsgang durch eine iithyllactat- und iithanolhaltige Filmmaske und eine antimikrobielle Tensid10sung M. GLOOR, W. WOLF und M. FRANKE • Synopsis -- A group of 15 healthy male subjects was treated with a face mask containing 1 '70 ethyl lactate and 50 % ethanol, while a matched group was treated with an antimicrobial surfactant solution with Aromox DMMCDW and Elfan NS242. The left side of the forehead was used as the test area, and a similar active agent free mask and a non-antimicrobial surfactant solution was applied to the right side of the forehead of each individual. Before the start of the treatment and 24 hours after the treatment the number of saprophytic bacteria in the pilosebaceous ducts was analyzed with the aid of a special anaerobic technique. The mask containing ethyl lactate and ethanol caused a significant reduction in the total bacteria and in the propionibacteria counts. The antimicrobial surfactant solution effected a significant decrease in the total bacteria count but did not alter the propionibacteria count. The results indicate that the test mask is an effective ache treatment. The efficacy of the treatment with the surfactant solution has not yet been determined. Saprophytiire Bakterien, insbesonders Propionibacterium acnes und Propionibacterium granulosum, sind ftir die Aufspaltung der Triglyceride des Talgdrtisensekretes im Talgdrtisenausftihrungsgangverantwortlich 121 }. Den dabei entstehenden freien Fettsiiuren wird eine comedonogene Wirkung zugeschrieben {5, 13, 14, 15}. Eine Reduktion dieser Bakterien durch ein antimikrobielles Agens mtigte also die Menge der freien Fettsiiuren und damit auch die Comedonenbildung bei der Akne ver- mindem. Augerdem wird diesen Bakterien auf einem anderen Weg (z. B. durch andere Ektofermente als Lipasen, Chemotoxine oder immuno- logische Reaktionen} eine Schltisselrolle ftir die Entstehung der entztind- Aus der Universitiits-Hautklinik Heidelberg {Geschiiftsf. iirztl. Ditektot: Prof. Dr. U. W. Schnyderl, Abteilung Dermatologie I {Schwerpunkt: Allgemeine Dermatologie und Venerologie I mit Poliklinik I)•rztl. Ditektot: Prof. Dr. U. W. Schnyderl. 487