185 Efficacy of Petrolatum (28) R. Ghadially, B.E. Brown, S.M. Sequeira-Martin, K.R. Feingold, and P.M. Elias, The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model, J. Clin. Invest., 95, 2281–2290 (1995). (29) M.C. Velarde, Epidermal barrier protects against age-associated systemic inflammation, J. Invest. Dermatol., 137, 1206–1208 (2017). (30) L. Hu, T.M. Mauro, E. Dang, G. Man, J. Zhang, D. Lee, G. Wang, K.R. Feingold, P.M. Elias, and M.Q. Man, Epidermal dysfunction leads to an age-associated increase in levels of serum inflammatory cytokines, J. Invest. Dermatol., 137, 1277–1285 (2017). (31) T. Tsakok, R. Woolf, C.H. Smith, S. Weidinger, and C. Flohr, Atopic dermatitis: the skin barrier and beyond, Br. J. Dermatol., 180, 464–474 (2019). (32) C.N. Palmer, A.D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S.P. Lee, D.R. Goudie, A. Sandilands, L.E. Campbell, F.J.D. Smith, G.M. O’Regan, R.M. Watson, J.E. Cecil, S.J. Bale, J.G. Compton, J.J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C.S Munro, B. El Houate, K. McElreavey, L.B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W.H.I. McLean, Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis, Nat. Genet., 38, 441–446 (2006). (33) K.L. Hon, J.S.C. Kung, W.G.G. Ng, and T.F. Leung, Emoillient treatment of atopic dermatitis: latest evidence and clinical considerations, Drugs Context, 7, 212530 (2018). (34) S. Harcharik and J. Emer, Steroid-sparing properties of emollients in dermatology, Skin Ther. Lett., 19, 5–10 (2014). (35) D.W. Miller, S.B. Koch, B.A. Yentzer, A.R. Clark, J.R. O’Neill, J. Fountain, T.M. Weber, and A.B. Fleischer Jr., An over-the-counter moisturizer is as clinically effective as, and more cost-effective than, prescription barrier creams in the treatment of children with mild-to-moderate atopic dermatitis: a randomized, controlled trial, J. Drugs Dermatol., 10, 531–537 (2011). (36) S. Xu, S. Immaneni, G.B. Hazen, J.I. Silverberg, A.S. Paller, and P.A. Lio, Cost-effectiveness of prophylactic moisturization for atopic dermatitis, JAMA Pediatr., 171, e163909 (2017). (37) R.A. Norman, Xerosis and pruritus in the elderly: recognition and management, Dermatol. Ther., 16, 254–259 (2003). (38) A. Sergeant and C. Munro, Ichthyosis: guide to recognition and current treatment options, Prescriber., 17, 35–42 (2006). (39) T. Czarnowicki, J.G. Krueger, and E. Guttman-Yassky, Skin barrier and immune dysregulation in atopic dermatitis: an evolving story with important clinical implications, J. Allergy Clin. Immunol., 2, 371–379 (2014). (40) J.J. Leyden, R.R. Marples, and A.M. Kligman, Staphylococcus aureus in the lesions of atopic dermatitis, Br. J. Dermatol., 90, 525–530 (1974). (41) P.Y. Ong, T. Ohtake, C. Brandt, I. Strickland, M. Boguniewicz, T. Ganz, R.L. Gallo, and D.Y.M. Leung, Endogenous antimicrobial peptides and skin infections in atopic dermatitis, N. Engl. J. Med., 347, 1151– 1160 (2002). (42) J. Nikolovski, G.N. Stamatas, N. Kollias, and B.C. Wiegand, Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life, J. Invest. Dermatol., 128, 1728–1736 (2008). (43) M. Odio and S.F. Friedlander, Diaper dermatitis and advances in diaper technology, Curr. Opin. Pediatr., 12, 342–346 (2000). (44) U. Blume-Peytavi, M. Hauser, L. Lünnemann, G.N. Stamatas, J. Kottner, and N. Garcia Bartels, Prevention of diaper dermatitis in infants—a literature review, Pediatr. Dermatol., 31, 413–429 (2014). (45) E. Sacks, W.J. Moss, P.J. Winch, P. Thuma, J.H. van Dijk, and L.C. Mullany, Skin, thermal and umbilical cord care practices for neonates in southern, rural Zambia: a qualitative study, BMC Preg. Childbirth, 15, 149–160 (2015). (46) L.A. Wilkie, The Archaeology of Mothering: An African-American Midwife’s Tale. (Routledge, New York, 2003).

186 JOURNAL OF COSMETIC SCIENCE (47) S. Nutten, Atopic dermatitis: global epidemiology and risk factors, Ann. Nutr. Metab., 66, s8–s16 (2015). (48) E.L. Simpson, T.M. Berry, P.A. Brown, and J.M. Hanifin, A pilot study of emollient therapy for the primary prevention of atopic dermatitis, J. Am. Acad. Dermatol., 63, 587–593 (2010). (49) E.L. Simpson, J.R. Chalmers, J.M. Hanifin, K.S. Thomas, M.J. Cork, W.H.I. McLean, S.J. Brown, Z. Chen, Y. Chen, and H.C. Williams, Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention, J. Allergy Clin. Immunol., 134, 818–823 (2014). (50) K. Horimukai, K. Morita, M. Narita, M. Kondo, H. Kitazawa, M. Nozaki, Y. Shigematsu, K. Yoshida, H. Niizeki, K-I Motomura, H. Sago, T. Takimoto, E. Inoue, N. Kamemura, H. Kido, J. Hisatsune, M. Sugai, H. Murota, I. Katayama, T. Sasaki, M. Amagai, H. Morita, A. Matsuda, K. Matsumoto, H. Saito, and Y. Ohya, Application of moisturizer to neonates prevents development of atopic dermatitis, J. Allergy Clin. Immunol., 134, 824–830 (2014). (51) F. Boralevi, M. Saint Aroman, A. Delarue, H. Raudsepp, A. Kaszuba, M. Bylaite, and G.S. Tiplica, Long-term emollient therapy improves xerosis in children with atopic dermatitis, J. Eur. Acad. Dermatol. Venereol., 28, 1456–1462 (2014). (52) G.S. Tiplica, F. Boralevi, P. Kommo, L. Malinauskiene, A. Kaszuba, C. Laurens, M. Saint-Aroman, and A. Delarue, The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study, J. Eur. Acad. Dermatol. Venereol., 32, 1180–1187 (2018). (53) A.J. Nopper, K.A. Horii, S. Sookdeo-Drost, T.H. Wang, A.J. Mancini, and A.T. Lane, Topical ointment therapy benefits premature infants, J. Pediatr., 128, 660–669 (1996). (54) M. Glatz, J-H Jo, E.A. Kennedy, E.C. Polley, J.A. Segre, E.L. Simpson, and H.H. Kong, Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis, PLOS One, 13, e0192443 (2018). (55) S. Seite, G.E. Flores, J.B. Henley, R. Martin, H. Zelenkova, L. Aguilar, and N. Fierer, Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment, J. Drugs Dermatol., 13, 1365–1372. (2014). (56) D.P. Smack, A.C. Harrington, C. Dunn, R.S. Howard, A.J. Szkutnik, S.J. Krivda, J.B. Caldwell, and W.D. James, Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. A randomized controlled trial, JAMA, 276, 972–977 (1996). (57) S.E. Jacob and W.D. James, Bacitracin after clean surgical procedures may be risky, J. Am. Acad. Dermatol., 51, 1036 (2004). (58) R.M. Campbell, C.S. Perlis, E. Fisher, and H.M. Gloster Jr., Gentamicin ointment versus petrolatum for management of auricular wounds, Dermatol. Surg., 31, 664–669 (2005). (59) K.A. Gehrig and E.M. Warshaw, Allergic contact dermatitis to topical antibiotics: epidemiology, responsible allergens, and management, J. Am. Acad. Dermatol., 58, 1–21 (2008). (60) W.D. James, Use of antibiotic-containing ointment versus plain petrolatum during and after clean cutaneous surgery, J. Am. Acad. Dermatol., 55, 915–916 (2006). (61) J.F. Schechter, R.D. Wilkinson, and J. Del Carpio, Anaphylaxis following the use of bacitracin ointment. Report of a case and review of the literature, Arch. Dermatol., 120, 909–911 (1984). (62) M.A. Vale, A. Connolly, A.M. Epstein, and M.R. Vale, Bacitracin-induced anaphylaxis, Arch. Dermatol., 114, 800 (1978). (63) K. Greenberg, J. Espinosa, and V. Scali, Anaphylaxis to topical bacitracin ointment, Am. J. Emerg. Med., 25, 95–96 (2007). (64) R.I. Nijhawan, L.A. Smith, and K. Mariwalla, Mohs surgeons’ use of topical emollients in postoperative wound care, Dermatol. Surg., 39, 1260–1263 (2013). (65) A. Morales-Burgos, M. Loosemore, and L. Goldberg, Postoperative wound care after dermatologic procedures: a comparison of 2 commonly used petrolatum-based ointments, J. Drugs Dermatol., 12, 163–164 (2013). (66) M. Saco, N. Howe, R. Nathoo, and B. Cherpelis, Topical antibiotic prophylaxis for prevention of surgical wound infections from dermatologic procedures: a systematic review and meta-analysis, J. Dermatol. Treat., 26, 151–158 (2015).