328 JOURNAL OF COSMETIC SCIENCE (18) N. Akhtar, A. Verma and K. Pathak, Feasibility of binary composition in development of nanoethosomal glycolic vesicles of triamcinolone acetonide using Box-Behnken design: In vitro and ex vivo characterization, Artif. Cells Nanomed Biotechnol. 45, 1–9 (2016). (19) I. John, J. I. D’Souza, K. Jagdish, S. Saboji, G. Killedar and N. Harinath, Design and evaluation of benzoyl peroxide microsponges to enhance therapeutic efficacy in acne treatment. Accepted for presentation in 20th FAPA Congress, Bangkok, Thailand 2004: 28. (20)V .Jain and R. Singh, Dicyclomine-loaded eudragit-based microsponge with potential for colonic delivery preparation and characterization, Tropical Journal of Pharmaceutical Research 9(1), 67–72 (2010). (21) M. Orlu, E. Cevher and A. Araman, Design and evaluation of colon-specific drug delivery system containing Flurbiprofen microsponges, International Journal of Pharmaceutics 318, 103–117 (2006). (22) C. Yerram, F. Shaik, B. Rubia Y., V. Amaravathi, B. Mahitha and U. Aruna, Microsponges: A novel drug delivery system for controlled delivery of topical drugs, Int. J. Pharm. Res. Anal. 2(2), 79–86 (2012). (23)V .B. Patel, A. N. Misra and Y. S. Marfatia, Preparation and comparative clinical evaluation of liposomal gel of benzoyl peroxide for acne, Drug Dev. Ind. Pharm. 27(8), 863–870 (2001b). (24) Y. Zhang, M. Huo, J. Zhou, A. Zou, W. Li, C. Yao and S. Xie, DDSolver: An add-in program for modeling and comparison of drug dissolution profiles, AAPS J 12(3), 263–271 (2010). (25) H. Ali, I. N. Muhammad and N. Aslam, Formulation design and optimization of aceclofenac tablets (100 mg) using central composite design with response surface methodology. Lat. Am. J. Pharm. 33(6), 1009–1018 (2014). (26) H. Song, X. Cao, J. Ruan, X. Peng, J. Wang, C. Wang and C. Bao, Application of rotatable central composite design in the preparation and optimization of poly (lactic-co-glycolic acid) nanoparticles for controlled delivery of HSA, Nano Biomedicine &Engineering 3, 34–41 (2011). (27) E. Markova, M. Kostovska and T. K. Olumcheva, Development of microsponges as drug delivery carriers: Optimization of formulation variables using sequential experimental strategy, Mac. Pharm. Bull. 62(Suppl.), 663–664 (2016). (28) L. E. Eichenfield, J. L. Jorizzo, T. Dirschka, A. F. Taub, C. Lynde, M. Graeber and N. Kerrouche, Treatment of 2,453 acne vulgaris patients aged 12-17 years with the fixed-dose adapalene-benzoyl peroxide combination topical gel: Efficacy and safety, J. Drugs Dermatol. 9:1395–1401 (2010). (29) F. Nielloud, J. P. Mestres and G. Marti-Mestres, Consideration on the formulation of benzoyl peroxide at ambient temperature choice of non-polar solvent and preparation of submicron emulsion gels, Drug Dev. Ind. Pharm. 28(7), 861–870 (2002). (30) U. Shinde, S. Pokharkar and S. Modani, Design and evaluation of microemulsion gel system of nadifloxacin, Indian J. Pharm. Sci. 74(3), 237–247 (2012). (31) P. M. Sarat, M. Ajay, B. B. Nagendra, P. Prathyusha, N. Audinarayana and R. K. Bhaskar, Microsponge drug delivery system: A review, Journal of Pharmaceutical Research 4(5), 1381–1384 (2011). (32) J. I. D’souza, In-vitro antibacterial and skin irritation studies of microsponges of benzoyl peroxide, Indian Drugs 38(7): 23 (2001). (33) G. Derringer and R. Suich, Simultaneous optimization of several response variables, J. Qual. Technol. 12, 214–219 (1980). (34) P. Arya and K. Pathak, Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: Optimization and pharmacokinetics, Int. J. Pharm. 460, 1–12 (2014). (35) M. A. Badawi and L. K. El-Khordagui, A quality by design approach to optimization of emulsions for electrospinning using factorial and D-optimal designs, Eur. J. Pharm. Sci. 58, 44–54 (2014).