788 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS convincing support for a mechanism of antiperspirant action which is based on contraction of the horny layer by denaturation. The intensity and depth of these denaturation-caused changes depend on the concentration and on the time of action of the tested agents. The influence of the hydration of the horny layer on the rate and intensity of penetration of topically applied ma- terials was stressed in the discussion. No anhidrotic effect of hexamethylene tetramine could be demonstrated on the forearm because here, under normal temperature conditions, sweat activity is lacking which is necessary for hydro- lysis and liberation of formaldehyde. Sodium hexametaphosphate by itself did not reduce sweating. In the control areas which had been moistened only with distilled water, greater expulsion of sweat was observed after some drying out (1-2 hours) modified imbibition of water in the periporal region was also observed. The discussion also concerned itself with the improved passage through the terminal portions of the eccrine sweat glands as a con- sequence of hydration (plasticization) of the periporal horny layer. Finally, the possibility of modifying the periporal layer's ability to bind water was explored. REFERENCES (1) Montagna, W., Eccrine Sweat Glands and Eccrine Sweating, Pergamon Press Inc., Publishers, New York 1956. (2) Kligman, A. M., in: W. Montagna and W. C. Lobitz, Jr. (Editors) The Epidermis, Academic Press, New York-London 1964, p. 387-430. (3) Kuno, Y., Human Perspiration, Charles Thomas Publishers, Springfield, USA, 1959. (4) Zfihejsk•, J., und Rovensk•, J., Arch. Min. exp. DermatoL 233, 227 (1968). (5) Rovensk•, J., und Zfihejsk•, J., Parfiimerie u. Kosmet. 51, 145 (1970). (6) Emrich, H. M., Pfliiger's Arch. ges. Physiol. Menschen Tiere 290, 298 (1966). (7) Potter, B., Ann. Rev. PhysioL 28, 159 (1966). (8) Malkinson, F. D., Arch. Environment. Health 11, 538 (1965). (9) Spier, H. W., Berufsdermatosen 15, 121 (1967). (10) Peiss, C. N., Randall, W. C., and Hertzmann, A. B., J. invest. Dermatol. 26, 459 (1956). (11) Randall, W, C., and Peiss, C. N., J. invest. DermatoL 28, 435 (1957). (12) Brown, W. K., and Sargent, F., Arch. Environment. Health 11, 442 (1958). (13) Brun, R., et Grasset, N., Dermatologica (Basel) 112, 357 (1956). (14) Brun, R., Dermatologica (Basel) 111, 316 (1955). (15) Jellinek, J. S., Kosmetologie, Dr. A. Hiltbig Verlag, Heidelberg 1967. (16) Plechner, S. L., in: E. Sagatin (Editor) Cosmetics, Science and Technology, Interscience PubL Inc., New York 1957. (17) Fiedler, H. P., Der SchweiJ•, Editio Cantor, Aulendorf/Wiirtt. 1968. (19) Janistyn, H., Taschenbuch der modernen Parf•'merie und Kosmetik, Wissenschaftliche Verlags- gesellschaft mbH, Stuttgart 1966. (19) Papa, Ch. M., and Kligman, A.M., J. invest. DermatoL 46, 193 (1966) J. invest. DermatoL 47, 1 (1966) J. invest. DermatoL 49, 139 (1967). (20) Shelley, W. B., Laskas, J. j., and Satanova, A., Arch. Dermatology 69, 713 (1954). (21) Klarmann, E.G., Acta Dermato-venereoL (Stockholm) 37, 59 (1957).

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