HUMAN SKIN GRAFTED NUDE MOUSE 259 .:. Figure 5. Stratum corneum of the human skin transplant. 5A. Full thickness stratum corneum. of the NMF four hours after application. The results shown are average values from duplicate studies. The data show a high stratum corneum uptake of urea, lactic acid, and alanine. However, alanine was found to be heavily located in the uppermost layers of stratum corneum, which suggests that the stratum corneum acts as a better reservoir for this ingredient. Table III illustrates the stratum corneum uptake of NMF condensate and the Aqualizer

260 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure 5. Stratum corneum of the human skin transplant. 5B. After l0 strippings. from their 10% w/w aqueous solutions and of Aqualizer incorporated into four different cosmetic bases in the same ratio. The results presented indicate that the highest stratum corneum uptake was from the aqueous solution of Aqualizer. The NMF condensate, which is a protein sugar complex, was retained by the stratum corneum at lower con- centrations. Therefore, the higher stratum corneum uptake of Aqualizer may be attrib- uted to the presence of urea and lactic acid which are known to act as diffusion pro-

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