SURFACT, ANTS AS ANTIMICROBIAL AGENTS 741 (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) (19) (20) c. A. Lawrence, "Surface Active Quaternary Ammonium Germicides," Academic Press, Inc., New York, 1950. J. J. Kabara, D. M. Swieczkowski, A.J. Conley and J.P. Truant, Fatty acids and derivatives as antimi- crobial agents,Antimicrob. Ag. Chemother., 2, 23-28 (1972). A. J. Conley and J. J. Kabara, Antimicrobial action of esters of polyhydric alcohols, Antimicro& Ag. Che- roother., 4, 501-506 (1973). J. J. Kabara, A. J. Conley and J.P. Truant, Relationship of chemical structure and antimicrobial activity ofalkyl amides and amines, Antimicrob. Ag. Chemother. 2,492-498 (1972). J.J. Kabara, R. Vrable, I. Ikeda and M. Okahara, Aminimides IV: antimicrobial activity of 1,1,1-tris (2- hydroxy-ethyl) amine-2-acylimides, J. Amer. Oil Chem. Soc., 54, 316-318 (1977). J.J. Kabara, Aminimides III: antimicrobial activity of various hexadecyl derivatives, J. Amer. Oil. Chem. Soc., 54, 202-204 (1977). J. J. Kabara, R. Vrable and M. Lie Ken Jie, Antimicrobial lipids: natural and synthetic fatty acids and monoglycerides, Lipids, 9, 753-759 (1977). J.J. Kabara, A. J. Conley, D.J. Swieczkowski, I. A. Ismail, M. Lie Ken Jie and F. D. Gunstone, Unsatu- ration in fatty acids as a factor for antimicrobial action, J. Med. Chem., 16, 1060-1063 (1972). S. Omura, J. Kutagiri, J. Awaya, T. Furukawa, I. Umezawa, N. Oi, M. Mizognchi, B. Oaki and M. Shindo, Relationship between the structure of fatty acid amide derivatives and their antimicrobial activities, Antimicro& Ag. Chemother., 6, 207-215 (1974). J.J. Kabara (to Med-Chem Labs, Inc.) U.S. Patent 4 002 775. J.J. Kabara (to Med-Chem Labs, Inc.) U.S. Patent 4 067 997. V. Wyss, B. J. Ludwig and R. R. Joiner, The fungistatic and fungicidal action of fatty acids and related compounds,Arch. Biochem., 7,415-425 (1945). W. J. McKillip, E. A. Sedor, B. M. Culbertson and S. Wawzonek, The chemistry of aminimides, Chem. Rev., 73,255-281 (1973). H. M. Jenkins and L. E. Anderson, The effect of oleic acid on the growth of monkey kidney cells (LLC- MK2), Exp. CellRes., 59, 6-10 (1970). H. M. Jenkins, L. E. Anderson, R. T. Holman, I. A. Ismail and F. D. Gunstone, The effect of isomeric c/s-octadecenoic acids on the growth of monkey kidney cells (LLC-MK2), Exp. Cell Res., 59, 1-5 (1970).
Book Review THE FRAGRANCE AND FLAVOR INDUSTRY, Wayne E. Dotland and James A. Rogers, Jr., Wayne E. Dorland Com- pany, Box 264, Mendham, New Jersey, 1977, XV + 444 pages. Price $30.00 + $2.00 for postage and handling. This most comprehensive text dealing with the fragrance and flavor industry consists of 18 chapters covering almost every aspect of this subject. The authors have succeeded in presenting the subject material in a most interesting and enlightening manner. Chapter I educates the reader about the nature of fragrances and flavor while Chapter II indicates the role of a flavor and fragrance in the success of a product. Many examples of this are given and the authors recount many 6f the success stories about products we all are familiar with. It was of particular interest to this reviewer to read about the start of the "Wrigley" empire and the success which followed. The same can be said of products such as "Coca-Cola," "Yardley's Lavender," "Shulton's Old Spice" and many others. Chapter III gives the reader an insight into how the fragrances and flavors are developed by quoting many of the individuals in the industry. Defini- tions, classification of both flavors and fragrances, and natural and synthetic raw materials are covered in Chapters IV through VIII in a most comprehensive manner. Some of the most important properties of each material is covered. The history and anatomy of the in- dustry (Chapters IX and X) make worth- while reading material since it gives the reader a personal insight into the fragrance and flavor industry. The history is covered by giving a brief review of the accomplishments of different individuals and the role they played in developing specific fragrance and flavor companies. Most of the present-day companies are in- cluded along with the names of the indi- viduals associated with them. The newcomer to the industry will enjoy reading Chapter XI since it deals with production processes and equip- ment. It was interesting and educational to read about the "enfieurage process," "distillation," "solvent extraction," "expression" and the other methods used to produce these materials. It gives much of the necessary background information to the formulator of cosmetic products which will enable one to better utilize these products. The scientific side of the industry has also been covered in Chapter XII which has been authored by Dr. Ernst Theimer. He covers in detail the composition of various materials and the basic chemistry involved. The remainder of the chapter is devoted to the use of instrumental analysis for the identification of each component. The use of gas chromatog- 742
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