344 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure 9. Chromatogram of NDELA (as NDELA-OAc) recovered from 20-ppb spiked hand cream. of the NDELA added to a cream sample was recovered by use of this method. It is possible that other nitrosamines may be isolated and identified from cosmetic products and raw materials by use of similar methodology. The relative low cost of the GC/ELCD system makes it an attractive option for dedicated trace level nitrosamine screening. ACKNOWLEDGMENTS The authors wish to thank Albert Cox of North 40 Instruments, Elgin IL, for providing the ceramic reaction tube used in this study, and Carl Williams of O.I. Corporation, College Station TX, for the use of the Model 4420 electrolytic conductivity detector. REFERENCES (1) H. J. Chou, R. L. Yates, and J. A. Wenninger, Screening cosmetic products for N-nitroso com- pounds by chemiluminescent determination of nitric oxide, J. Assoc. Off. Anal. Chem., 70, 960-963 (1987). (2) CTFA Tech/RegNotes, 1(3), 1 (1987). (3) L. R. Ember, Nitrosamines: Assessing the relative risk, Chem. Eng. News, March 31, 1980, p. 20. (4) W. Lijinsky, cited in F. E. Bently, Nitrosodiethanolamine as an environmental hazard, CTFA Task Force Chemistry Committee Meeting, April 27, 1977. (5) H. Druckrey, R. Preussmann, S. Ivankovic, and S. Schmahl, Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen and Bd-Ratten, Z. Krebsforsch, 69, 103-201 (1967). (6) W. Lijinsky, M.D. Reuber, and W. B. Manning, Potent carcinogenicity of nitrosodiethanolamine in rats, Nature, 11, 589-590 (1980).
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