BOOK REVIEWS SPECIFIC METHODS OF ANALYSIS, consulting editor Samuel E. Q. Ashley, pages 995-1118, Volume 53, Annals of the New York Academy of Sciences, New York, N.Y. 1951. Price $2.50. A cardboard covered reprint of portions of the Academy Annals deals with specific methods of anal- ysis, but they are all out of the present scope of the toilet goods in- dustry. It is a typical Academy publication, well printed and author- itative.--M. G. t)EN. P^P^IN, Consulting Editor M. L. Tainter pages 143-296, Volume 54, Annals of the New York Academy of Sciences, New York, N.Y. 1951. Price $3.00. Ten chapters or contributions with a foreword by M. L. Tainter and O. H. Buchanan constitute this typical Academy publication. It is a study of the proteolytic enzyme obtained from Carica Papaya, a useful tropical plant. Following a general description of the plant and the processing of its latex, the monograph includes an comprehensive review of the litera- ture on its therapeutic significance. The other papers or chapters are de- voted to a discussion of laboratory techniques. Hwang & Ivy's review of the literature is indeed thorough and the following comment to be made is not intended to convince the reader otherwise. But the authors did miss the scattered and indeed few references to the cosmetic use of both papain or the fresh latex from the fruit. At least one locally known cosmetic line offers papaya cosmetics in Florida. However the reference to its sensitizing proper- ties reminds one that Bromelin from fresh pineapple, another pro- teolyt!c enzyme, is also a sensitizer. It •s a well-done monograph, clearly illustrated, and definitely needed to fill a gap in the scientific literature on Papain and, by rela- tionship, papaya or pawpaw as it is also known.--M. G. dEN. T•E i\I^NUF^CTUP, E OF INTEP,ME- DIATES AND DYES, by G. H. Frank, M.Sc. (Leeds), F.R.I.C. Chemical Publishing Co., Inc., New York, N.Y., 1952. 177 pp. $4.00. This is a very brief discussion of d.ye manufacturing as done in Brit- ain. The plant and equipment are describedin outline. The author de- scribes the processes from the point of isolation from coal tar through the preparation of intermediates to the finished dyes. Emphasis is placed on preparation of intermedi- ates. Azo dyes, anthraquinone dyes, and sulfur dyes are described. The author does not mention that most of the more complex dyes are actu- ally mixtures of the several compo- nents produced in the reactions of the intermediates. Although this fact is well known in the industry, it is rarely mentioned in any publica- tions. From the standpoint of the chem- ist in the food, drug, or cosmetic field, the book will not indicate

BOOK REVIEWS 79 very much about the production of the purified dyes of the type certi- fied for use in this country. No mention is made of the fluorescein or triphenylmethane dyes that repre- sent a large portion of the certified colors used. The analytical methods given do not reflect the practices of modern, w. ell-equipped analytical laborato- ries. The chapter on health hazards in the industry is so brief and incom- plete that it might serve to minimize a serious problem. The book will be of little value to the chemist in a dye plant. It will, however, be of considerable assist- ance to the student who wishes to obtain an idea of the procedures followed in commercial production of some types of dyes. The author states in his preface that the book was intended for the student or junior chemist. He has produced a well-written text that can be recommended to those groups. --G. RouF. P.m CLARK. FORMULAIRE DE PARFUMERIE, 3 volumes, by Rene Cerbelaud (P. Velon, E. Bourdet, L. Bornand, and E. Sidi wrote the revisions), 3041 pages, illustrated and indexed, 6 X 91/2 inches. Editions Opera, Paris. Price 19,000 francs. The Cerbelaud books are known wherever there are outstanding per- fumers and cosmetic chemists. Though written in French, the work does not suffer at all. The cosmetic and perfume sciences have grown rapidly, but Cerbelaud is no longer here to know. It was therefore fitting that the books he wrote be continued the toilet goods world is fortunate indeed that a cosmetic chemist, a colorist, a perfumer, and an allergist collaborated to bring this mammoth work up to date. The renowned Cecbelaud pro- duced a great but confused work as far as this reviewer was ever able to determine. The revisers however have added their material at the end of each of the old volumes, and in an orderly fashion. In other words, the old material stands as it was originally published and the new material is added at the end of each volume. Both Cerbelaud and the current writers have given credit where ma- terial is quoted from other sources. Cerbelaud's earlier material in Volume I consists of a text on Per- fumery, with a discussion of the raw materials used. Bourdet's contributions on colors could be more complete if the FD&C designations together with either Schultz or Colour Index numbers were included. The sec- tion on soap colors is good. It is noted that neither FD&C Yellow No. 3 and 4 nor FD&C Red No. 32 are included among the oil-soluble colors, all of which are believed by some foreign countries to be cancer- ogenic. However, Butter Yellow is included--yet it is considered unsafe in this country. Dr. Sidi gives a scholarly report on the allergic responses due to cos- metics, illustrated from his own col- lection of photographs of patients coming to his clinic. Each majo• type of cosmetic is discussed. Many of the chapters are illus- trated. One is a bit concerned with the authors' statement that, in 1948, 66 cases of cosmetic sensitization were found among 519 cases of der- madds reporting in the authors' clinic. Broken down, the worst of-• fenders were brilliantines 32 cases, nail polish 15 cases, lipsticks 11 cases, and p-phenylenediamine dyes 8 cases. American cold-wave sup- pliers will not agree with this aller- gist's findings on thioglycolates. In Volume II, Mr. Velon reviews the standards of the T.G.A. for