2001 ANNUAL SCIENTIFIC SEMINAR 353 were washed with shampoo comprising the NanoSal TM, and analyzed by SEM. Figure 2 shows the adhesion of NanoSal TM onto hair from a shampoo application. Figure 2: Adhesion of NanoSal TM to hair from shampoo application. Conclusions A rational scientific approach is key to develop effective controlled release systems for skin care products. The process of developing new controlled release systems for skin has several major steps: screening and selection of materials, processing optimization and evaluation of performance. ACRS based on bioadhesive nanospheres was designed to deliver a wide range of active ingredients. The key to success is tailoring the system to the specific application. References 1. S. Shefer et. al., Controlled Release Society, Annual meeting in Paris 1999 2. Patent application, 2000 to Salvona LLC 3. Crank J. and Park G. S., Diffusion in Polymers, Academic Press, New-York, 1969 4. Konos W., Ed. Barrier Polymers and Structures, ACS Series, Washington DC, 1990