200 JOURNAL OF COSMETIC SCIENCE (18) H. Vlassara, The AGE-receptor in the pathogenesis of diabetic complications, Diabetes Metab. Res. Rev., 17, 436–443 (2001). (19) S. Rowan, E. Bejarano, and A. Taylor, Mechanistic targeting of advanced glycation end-products in age- related diseases, Biochim. Biophys. Acta - Mol. Basis Dis., 1864, 3631–3643 (2018). (20) T. Laughlin, Y. Tan, B. Jarrold, J. Chen, L. Li, B. Fang, W. Zhao, M. Tamura, A. Matsubara, G. Deng, X. Wang, and T. Hakozaki, Autophagy activators stimulate the removal of advanced glycation end products in human keratinocytes, J. Eur. Acad. Dermatology Venereol., 34, 12–18 (2020). (21) A. Salminen and K. Kaarniranta, SIRT1: Regulation of longevity via autophagy, Cell Signal., 21, 1356– 1360 (2009). (22)C . Ott, K. Jacobs, E. Haucke, A. Navarrete Santos, T. Grune, and A. Simm, Role of advanced glycation end products in cellular signaling, Redox. Biol., 2, 411–429 (2014). (23)C . Chen, J.-Q. Zhang, L. Li, M. Guo, Y. He, Y. Dong, H. Meng, and F. Yi, Advanced glycation end products in the skin: Molecular mechanisms, methods of measurement, and inhibitory pathways, Front. Med., 9, 1–17 (2022). (24) Z. Ren, H. He, Z. Zuo, Z. Xu, Z. Wei, and J. Deng, The role of different SIRT1-mediated signaling pathways in toxic injury, Cell Mol. Biol. Lett., 24, 1–10 (2019). (25) W. Li and A. N. Kong, Molecular mechanisms of Nrf2-mediated antioxidant response, Mol. Carcinog., 48, 91–104 (2009). (26) P. J. Thornalley, The glyoxalase system in health and disease, Mol. Aspects Med., 14, 287–371 (1993). (27) N. Liu, H. Matsumura, T. Kato, S. Ichinose, A. Takada, T. Namiki, K. Asakawa, H. Morinaga, Y. Mohri, A. De Arcangelis, E. Geroges-Labouesse, D. Nanba, and E. K. Nishimura, Stem cell competition orchestrates skin homeostasis and ageing, Nature, 568, 344–350 (2019). (28)C . Cao, S. Lu, R. Kivlin, B. Wallin, E. Card, A. Bagdasarian, T. Tamakloe, W. Wang, X. Song, W. M. Chu, N. Kouttab, A. Xu, and Y. Wan, SIRT1 confers protection against UVB- and H 2O 2-induced cell death via modulation of p 53 and JNK in cultured skin keratinocytes, J. Cell Mol. Med., 13, 3632–3643 (2009).