TOPICAL USES OF SEVERAl, ANTIBIOTICS 313 (18) (19) (20) (21) (22) (23) (24) (25) (26) (27) (28) (29) (30) McCreight, C. E., "Experimental Studies on Some Cell Types in the Epidermis of the Mouse," .4nat. Record, 121, 338 (1955). Ma, C. K., and Cowdry, E. V., "Aging of Elastic Tissue in Human Skin," y. Geront., 5, 203 (1950). Pease, D.C., "Electron Microscopy of Human Skin," .rim. •..4nat., 89, 469 (1951). Percival, C. H., "The Skin in Old Age," Practitioner, 172, 510 (1954). Strauss, J., and Necheles, H., "Variation, in Dermal Absorption with Age," 5'. Lab. and Clin. Med., $$, 612 (1948). Strobel, H., "Die Gewebsveranderungen der Haut im Verlauf des Lebens," glrch. Der- matol. u Syphilis, 186, 636 (1948). Thompson, R. C., "Dermatologic Problems of Geriatric Patients," 7. Tenn. Med..4ssoc., 46, 316 (1953). Thuringer, J. M., and Cooper, Z. K., "The Mitotic Index of the Human Epidermis, the Site of Maximum Cell Proliferation, and the Development of the Epidermal Pattern," .4nat. Record, 106, 255 (1950). Traub, E. F., and Spoor, H. J., "Aging Skin with Particular Reference to Small Growths Appearing Late in Life," 7..4m. Geriat. Soc., 1, 805 (1953). Tunbridge, R. E., Tattersall, R. N., Astbury, D. A., and Reed, W. T., Royal Clinical Society, 11, 315 (1952). Cited from "Annotations"--Lancet, 5, 283 (1953). Unna, P. G., "The Histopathology of the Diseases of the Skin," New York, Macmillan and Company (1896), pp. 976-984. Wells, G. C., "Senile Changes in the Skin of Man," •..4m. Geriat. Soc., 2, 535 (1954). Zahon, S. J., Goldberg, A. L., and Forman, J., "Geriatric Dermatoses'. A Survey of the Skin of the Aged," Illinois Med. 5:., 101, 37 (1952). TOPICAL USES OF SEVERAL ANTIBIOTICS: VEHICLES EMPLOYED* By WM. BURDELL BAKER /lntibiotic Division, S. B. Penick & Co., New York 8, N.Y. ANTIBIOTICS such as bacitracin, neomycin and tyrothricin are used mainly for topical and other local applications and are also used orally. The major objective of this particular study is to review salient features of these antibiotics and to present the status of some of the vehicles or bases that have been employed with them. Also, some vehicle formulas similar to those which have been employed for other chemical agents and drugs, such as sulfonamides, are suggested as being adaptable for use with these antibiotics. Various literature reports dealing generally with the above antibiotics have included the subject of bases. Some investigators have given logical reasons for preferring grease bases for topical application of medicaments, while others have favored aqueous bases where possible. Still others ap- parently do not think the nature of the base important because, in discuss- ing applications and results, they mention the vehicle used, but do not state the formula. * Presented at the May 13, 1955, Meeting, New York City.

TOPICAL USES OF SEVERAl, ANTIBIOTICS 313 (18) (19) (20) (21) (22) (23) (24) (25) (26) (27) (28) (29) (30) McCreight, C. E., "Experimental Studies on Some Cell Types in the Epidermis of the Mouse," .4nat. Record, 121, 338 (1955). Ma, C. K., and Cowdry, E. V., "Aging of Elastic Tissue in Human Skin," y. Geront., 5, 203 (1950). Pease, D.C., "Electron Microscopy of Human Skin," .rim. •..4nat., 89, 469 (1951). Percival, C. H., "The Skin in Old Age," Practitioner, 172, 510 (1954). Strauss, J., and Necheles, H., "Variation, in Dermal Absorption with Age," 5'. Lab. and Clin. Med., $$, 612 (1948). Strobel, H., "Die Gewebsveranderungen der Haut im Verlauf des Lebens," glrch. Der- matol. u Syphilis, 186, 636 (1948). Thompson, R. C., "Dermatologic Problems of Geriatric Patients," 7. Tenn. Med..4ssoc., 46, 316 (1953). Thuringer, J. M., and Cooper, Z. K., "The Mitotic Index of the Human Epidermis, the Site of Maximum Cell Proliferation, and the Development of the Epidermal Pattern," .4nat. Record, 106, 255 (1950). Traub, E. F., and Spoor, H. J., "Aging Skin with Particular Reference to Small Growths Appearing Late in Life," 7..4m. Geriat. Soc., 1, 805 (1953). Tunbridge, R. E., Tattersall, R. N., Astbury, D. A., and Reed, W. T., Royal Clinical Society, 11, 315 (1952). Cited from "Annotations"--Lancet, 5, 283 (1953). Unna, P. G., "The Histopathology of the Diseases of the Skin," New York, Macmillan and Company (1896), pp. 976-984. Wells, G. C., "Senile Changes in the Skin of Man," •..4m. Geriat. Soc., 2, 535 (1954). Zahon, S. J., Goldberg, A. L., and Forman, J., "Geriatric Dermatoses'. A Survey of the Skin of the Aged," Illinois Med. 5:., 101, 37 (1952). TOPICAL USES OF SEVERAL ANTIBIOTICS: VEHICLES EMPLOYED* By WM. BURDELL BAKER /lntibiotic Division, S. B. Penick & Co., New York 8, N.Y. ANTIBIOTICS such as bacitracin, neomycin and tyrothricin are used mainly for topical and other local applications and are also used orally. The major objective of this particular study is to review salient features of these antibiotics and to present the status of some of the vehicles or bases that have been employed with them. Also, some vehicle formulas similar to those which have been employed for other chemical agents and drugs, such as sulfonamides, are suggested as being adaptable for use with these antibiotics. Various literature reports dealing generally with the above antibiotics have included the subject of bases. Some investigators have given logical reasons for preferring grease bases for topical application of medicaments, while others have favored aqueous bases where possible. Still others ap- parently do not think the nature of the base important because, in discuss- ing applications and results, they mention the vehicle used, but do not state the formula. * Presented at the May 13, 1955, Meeting, New York City.