TOPICAL USES OF SEVERAL ANTIBIOTICS 319 In the examples tabulated on page 318, where similarity of components exists, it is indicated by a series of dots on the same line. Directions: Melt the beeswax and liquid petrolatum together at 65øC. Dissolve triethanolamine and neomycin sulfate (or make suspension with tyrothricin) in the water and heat to 65øC. Add oil phase to aqueous phase with stirring, remove from heat and continue stirring until congealed. Neomycin sulfate ...... 0 5 Liquid petrolatum ..... 40 Peanut oil ............ 2 Triethanolamine ....... 1 Stearic acid ........... 3 Cetyl alcohol .......... 2 Water ................ 50 Directions: Melt the cetyl petrolatum together at 65øC. 42 15 43 00 00 50 Tyrothricin ........... O. 05 gm. gm. gm. gm. gm. gm. gm .................... ml .................... 50.95 ml. alcohol, stearic acid, peanut oil and liquid Dissolve the neomycin sulfate (or suspend the tyrothricin) in the water, add the triethanolamine and warm to same temperature. Add the aqueous to oil phase, with stirring. Remove from water bath, and stir until congealed. Neomycin sulfate ....... 0.5 gm. White petrolatum ....... 20.0 gin. Glycerin ............... 11.8 gm. Pectin ................. 5.0 gm. Methyl parahydroxyben- zoate ................ 0.2 gm. Ringer's solution* ....... 62.5 mi. Tyrothricin ........... 0.05 gm. ................... ................... 62.95 mi. Directions: Wet the pectin and methylparaben with glycerin, add Ringer's solution previously heated to boiling, stir well to make smooth paste. Keep mixture on water bath and add previously melted white petrolatum gradually with constant stirring. Remove from water bath and continue stirring until cool. Dissolve the neomycin sulfate (or suspend the tyrothricin) in a reserved portion of Ringer's solution, gradually add this to base with stirring, using additional Ringer's solution to insure com- plete transfer. * Ringer's solution Sodium chloride ......................................................... 8.60 gm. Potassium chloride ...................................................... 0.30 gm. Calcium chloride ..................................................... 0.33 gm. Distilled water ........................................................ 1000.00 mi. Water-in-Oil-Bases Neomycin sulfate ...... 0.5 gin. Tyrothricin ............ 0.05 gm. Aquaphor* q. s ....... 100.0 gm ...................... Directions: Simple incorporation by combining the base portionwise ("geometric dilution"). * Aquaphor is said to consist of "6 per cent of a group of esters and alcohols in aliphatic hydrocarbons." Manufactured by Duke Labs., Inc., Stamford, Conn.

320 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Neomycin sulfate ....... 0.5 gm. Tyrothricin ........... 0.05 gm. W6ol fat ............... 20.0 gm .................... White wax ............. 10.0 gm .................... White petrolatum ....... 69.5 gm .................... 69.95 gm. Bacitracin ............... 500 units/gin. (approx. 1 gin.) Wool Fat ................ 20.0 gin. White Wax .............. 10.0 gin. White Petrolatum ........ 69.0 gin. Directions: Melt ingredients according to melting points of base. Add the antibiotics by simple incorporation in the congealed base, portionwise ("geometric dilution"). Vanishing Creams Neomycin sulfate ....... 0.5 gin. ß Tyrothricin ........... 0.05 gin. Liquid petrolatum (low ................... viscosity) ............ 15.0 gm .................... Stearic acid ............ 5.0 gm .................... Lanolin ................ 5.0 gm .................... Glyceryl monostearate... 12.0 gm .................... Petrolatum ............. 20.0 gm .................... Water ................. 42.5 ml .................... 42.95 ml. Directions: Dissolve the neomycin sulfate (or suspend the tyrothricin) in the water. Melt the other components of the base together, considering proper melting points in order. Add aqueous phase to oil phase and stir well. Remove from heat (water bath at 65øC.), and continue to stir until congealed. Neomycin sulfate ....... 0.5 gin. Cetyl trimethyl ammo- nium bromide ........ 1.0 gin. Castor oil .............. 25.0 gin. Beeswax ............... 1.8 gm. Wool fat ............... 1.8 gm. Cetyl alcohol ........... 5.0 gin. Glycerin ............... 10.0 gm. Water ................. 56.9 ml. Tyrothricin ........... 0.05 gm. ................... 57.35 ml. Directions: The oil phase is castor oil, beeswax, wool fat, and cetyl alco- hol. The aqueous phase is neomycin sulfate (dissolved in water) or tyro- thricin (suspended in water), cetyl trimethyl ammonium bromide, glycerin, and water. Heat each phase to 60øC., add the aqueous phase to the oil phase, stir well, remove from water bath, continue to stir until congealed. "Washable" Jelly Bases Neomycin sulfate ....... 0.5 gm. Tyrothricin ........... 0.05 gm. Pectin ................. 10.0 gm .................... Benzoic acid ........... 0.2 gm .................... Ringer's solution ........ 89.3 ml .................... 89.75 ml. .(Glycerin may be substituted for Ringer's solution, for its antidrying effect.)