ACETYLATED LANOLIN DERIVATIVES 353 Formula No. 7 Baby Oil or Brilliantine Acetylated lanolin alcohols (liquid fraction)... or ... Acetylated lanolin ........................................................... 5.0% Mineral oil ................................................................. 95.0 Formula No. 8 Sunscreen Oil Acetylated lanolin alcohols (liquid fraction)... or ... Acetylated lanolin .......................................................... 5.0% Sunscreen ................................................................... 2.0 Isopropyl myristate .......................................................... 43.0 Mineral oil .................. ' ............................................... 50.0 Procedure (for both): Where the acetylated lanolin is used heat slightly in the mineral oil until clear. Remove from heat and add the remaining ingredients and mix cold. These formulas are typical anhydrous solutions which remain brilliantly clear. Stable, hazy, colloidal lanolin solutions can also be prepared by combining the acetylated lanolin derivatives with mineral oil and ordinary lanolin. CREAM SHAMPOO The acetylareal products may be added to cream shampoo formulations without reducing foaming as is the case when lanolin U.S.P. is used. Other advantages of using them as superfarting agents are increased softness and manageability of the hair. Formula No. 9 Acetylated lanolin alcohols (liquid fraction)... or ... Acetylated lanolin ....................................................... 2.0% Stearic acid ................................................................ 8.0 Glyceryl monostearate, neutral ................................................ 2.0 Amerchol L-101 ............................................................. 4.0 Veegum, dry ................................................................ 1.5 Duponal WA paste .......................................................... 60.0 Water ...................................................................... 20.0 Triethanolamine ............................................................. 1.5 Sodium hydroxide ............................................................ 5 Potassium hydroxide .......................................................... 5 Preservative ................................................................ q. s. Procedure: Place all ingredients in one container and mix slowly while heating to 80øC. Continue mixing until cool and the desired consistency. Aerosols have become an important factor in the cosmetic and pharmaceu- tical industries. This formulation for a protective hand cream was not developed by us, but by the aerosol laboratory of a perfume company.* The pH of the concentrate is 6.5. Stability and lack of corrosion was es- tablished after sixty days at 100øF., and at --20øF. This product is a glossy white cream which imparts a non-greasy film having interesting protective qualities. The modified lanolin products have applications in lipsticks because of their plasticity, emollience, solubility and penetration effects. Although

354 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Formula No. 10 Arerosol Hand Cream 'Acetylated lanolin alcohols (liquid fraction) ........................... 3.0% A Stearic acid .......................................................... 2.6 ß Glyceryl monostearate ................................................ 3.0 ' Polyoxyethylene lanolin derivative ............................... 3.0 Preservative ..................................................... 0.1 B Triethanolamine ................................................ 1.0 Propylene glycol .................................................. 3.0 Water ............................................................. 84.0 C Perfume ............................................................ 0.3 9:2% Actives 8% Propellent--F-114-- 40% F-12 -- 60% 100% Procedure: Heat A and B separately to 80øC. Add B to A slowly while mixing when cool add C and mix. * Dodge and Olcott, Inc. bromo acids are insoluble in them, these materials, especially the acetylated lanolin alcohol product, do seem to increase penetration and staining. The hydrophobic property is also an advantage since it reduces the tackiness due to water absorption from the lips. The acetylated lanolin derivatives described and discussed in this report can be used advantageously in many other types of products for topical application, and merit continued investigation. SUMMARY AND CONCLUSIONS 1. New lanolin derivatives were prepared by acetylation oflanolin hy- droxyesters. Acetylated lanolin is particularly described and its chemistry discussed. 2. A liquid fraction ofacetylated lanolin alcohols, of interest in cosmetics was also prepared, and is described. 3. As a result of the acetylation, the hydrophilic water-binding capacity disappeared and the material became hydrophobic in character. 4. Crystal-clear, fluid solutions of the acetylated products were ob- tained in mineral oil. 5. The tackiness, characteristic of lanolin-compounded cosmetics, was replaced by a waxy feel. 6. The acetylated products were found to be stable under conditions of normal use. 7. Typical cosmetic formulations prepared with these derivatives indi- cate their value in a wide variety of products for topical use. REFERENCES (1) Bertram, S. H., 7. Arm. Oi! Chemists' $oc., 26, 454 (1949). (2) Truter, E. V., •uart. Rev., 5, 390 (1951). (3) Tie&, J., and Truter, E. V., ChemDtry & Industry, 403 (1952).