PREPRINTS OF THE 1996 ANNUAL SCIENTIFIC MEETING 249 Table I Kinetics of Distribution of Glycolic Acid (Expressed as Percent of Applied Dose +-- Standard Deviation) in Various Compartments of Hairless Mouse Skin After 1-Hour Topical In Vivo Application of Various Formulations (n = 3) Scrarum Living Time corneum Stratum skin Urinary (h) Swabs surface corneum strata excretion Recovery O/W emulsion 0 60.8 + 1.3 25.5 + 0.9 2.9 + 0.7 0.85 + 0.28 0.04 +- 0.03 90.0 +- 2.0 1 56.1 +- 6.1 24.9 + 2.6 4.9 + 2.9 0.77 +- 0.27 0.06 + 0.02 86.8 +- 2.1 2 57.2 + 2.3 21.6 +- 0.9 6.9 +- 1.4 0.87 + 0.30 0.10 +- 0.03 86.6 +- 0.3 4 54.0 +- 2.0 20.3 -+ 4.0 7.8 -+ 1.0 0.98 +- 0.23 0.14 -+ 0.05 83.2 +- 1.8 8 53.9 +- 1.5 16.2 +- 1.9 8.1 + 0.7 0.89 +- 0.26 0.36 +- 0.05 79.3 +- 1.8 W/O emulsion 0 46.9 + 5.2 22.4 +- 1.5 6.0 +- 0.2 0.77 + 0.40 0.11 + 0.02 76.2 +- 6.7 1 54.1 +- 3.4 18.8 +- 2.0 7.6 + 1.4 0.63 +- 0.31 0.20 +- 0.06 81.3 + 5.2 2 50.0 +- 3.2 18.1 +- 2.5 8.2 +- 1.2 0.88 + 0.29 0.32 +- 0.07 77.5 +- 0.7 4 57.4 + 4.7 12.1 + 2.6 5.0 +- 0.9 0.66 +- 0.28 0.35 + 0.15 75.6 +- 5.1 8 55.1 +- 7.2 16.2 +- 8.2 6.1 + 0.4 0.57 +- 0.04 0.47 +- 0.33 78.5 +- 1.6 Noa- 1 liposomes 18.4 -+ 4.2 49.7 -+ 4.5 17.2 +- 4.0 2.59 +- 0.90 0.22 -+ 0.07 88.1 +- 3.2 23.1 +- 4.9 32.1 +- 3.5 20.6 -+ 3.4 2.83 +- 0.84 0.40 +- 0.07 79.0 +- 3.6 23.4 +- 5.0 26.0 +- 4.2 19.8 +- 5.8 2.95 + 0.82 1.15 +- 0.11 72.5 +- 7.0 19.7 + 4.5 29.8 + 6.0 17.5 +- 8.1 2.02 + 0.80 1.81 + 0.49 69.0 +- 8.0 16.3 +- 2.0 28.0 +- 5.3 10.9 + 3.9 0.81 +- 0.27 2.10 +- 0.59 58.1 +- 5.5 Noa-2 liposomes 0 13.2 + 2.0 52.6 + 5.1 13.6 +-- 3.8 1.92 +- 0.93 0.15 +_ 0.03 81.5 +- 2.3 1 12.6 +- 3.3 48.8 +- 8.7 14.7 ___ 4.0 1.45 +-- 0.15 0.13 +- 0.02 77.6 --- 2.3 2 21.2 +_ 2.6 41.6 +-- 3.5 9.9 +- 2.6 1.02 ___ 0.39 0.20 +_ 0.10 73.9 +- 3.0 4 17.6 +- 3.7 33.1 --- 5.7 14.7 +_ 2.5 1.15 + 0.34 0.49 +-- 0.11 67.1 --+ 4.1 8 11.0 +- 0.8 34.3 + 1.3 14.6 +_ 1.2 0.95 +- 0.36 0.83 +- 0.12 61.7 +- 2.6

250 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure 1. Hairless rat skin. Figure 2. Hairy rat skin.