ABSTRACTS 537 Physiological and Morphological Changes of the Facial Physiological and Morphological Changes of the Facial Skin with Advancing Age and Self-Consciousness in Skin with Aging and Self-Consciousness in Japanese Men Japanese Men (First Report) ---Differences between Facial (Second Report) ---Changes in the Wrinkle Formation and Sites and Changes with Season and Advancing Age of Skin Facial Skin Color with Advancing Age and Men's Fundamental Properties--- Kazuyoshi Onishi, Ayumi Yamaguchi, Ken-ichi Kuriyama, Yoshio Tsujino, Nobuki Fujiwara Central Research Laboratories, Mandom Corp., 5-12, Juniken-cho, Chuo-ku, Osaka 540-8530, Japan Consciousness of Facial Cares--- Ayumi Yamaguchi, Kazuyoshi Onishi, Ken-ichi Kuriyama, Yoshio Tsujino, Nobuki Fujiwara Central Research Laboratories, Mandom Corp., 5-12, Juniken-cho, Chuo-ku, Osaka 540-8530, Japan The visual examination of wrinkle formation and the measurement of skin color were conducted to investigate The physiological study of Japanese men's facial skin and the changes of appearance in Japanese men's faces with differences between men and women in facial skin has advancing age. At the comers of the eyes, the deepest linear rarely been reported. Thus, we conducted non-invasive wrinkles developed deeper, whereas most fine wrinkles measurement of skin conductance, skin surface lipid and developed at the suborbital site with advancing age. The transepidermal water loss and skin mechanical properties wrinkle formation was accentuated at around 40 in the and analyzed those changes with seasons, with advancing comer of the eyes and around 50 in the suborbital site. age and those differences between men and women. Our Individual variation in wrinkle formation was more purpose was to investigate the fundamental physiological remarkable in the suborbital site than in the corners of the properties of Japanese men's facial skin. The results of our eyes. The subjects having more accentuated wrinkles at the study established the following facts : I. In skin suborbital site among same generation (40's) tended to conductance and skin surface lipid production, the show higher TEWL and lower skin conductance. An physiological differences between the T-zone and U-zone increase in redness and decrease in brightness of facial skin of men were more remarkable than that of women, 2. with advancing age were confinned. Before their 40's, a Contrary trends were shown in T-zone and U-zone for the seasonal change in which the facial brightness became seasonal changes of TEWL and final distension lower in summer and higher in winter was detected, respectively, 3. The lower cheek was the driest part in whereas after the 40's, no significant difference in the men's facial skin throughout the year, 4. A high negative seasonal change was found. The aging symptom of men correlation coefficient was confirmed between total was obviously worsened at about 40 years old. distension and actual age in men's facial skin and total Synchronously, they began to recognize the changes in distension can serve as an index of aging change in appearance of their own faces. Men who were interested in Japanese men's facial skin, 5. Differences in the methods of skin care products were not many in contrast with women, shaving and the use of sunscreen cosmetics had an whereas they hoped to look much younger and recognized influence on aging changes in Japanese men's facial skin. that skin care is necessary.

]. Cosmet. Sci., 58, 539-545 (September/October 2007) Abstracts International Journal of Cosmetic Science Vol. 29, No. 2, 2007* Review Article of physiological functions as cellular differentiation or gene regulation. It has been suggested that deimination plays a Update on peptidylarginine deiminases and deimination in role in many major diseases such as rheumatoid arthritis, skin physiology and severe human diseases multiple sclerosis, Alzheimer's disease and psoriasis. Five M.-C. Mechin*, M. Sebbag*, J. Arnaud*, R. Nac f at*1, C. human genes (PADis), encoding five highly conserved Foulqu t *• V. Adoue*, F. Coudane*, H. Duplan , A.-M. paralogous enzymes (PADl-4 and 6), have been Schmitt , S. Chavanas*, M. Guerrin*, G. Serre* and M. characterized. These genes are clustered in a single locus, Simon* at l p35-36 in man. Only PADl -3 are expressed in human *CNRS-University of Toulouse III, UMR5165, Institut epidermis. PADs seem to be controlled at transcriptional, Federatif de Recherche Claude de Preval, IFR30 translational and activity levels and they present particular (INSERM-CNRS-Universite Paul Sabatier-CentrJ? substrate specificities. In this review, we shall discuss these Hospitalier Universitaire de Toulouse), Toulouse and T main biochemical, genetic and functional aspects of PADs lnstitut de Recherche Pierre Fabre, Toulouse, France together with their pathophysiological implications. Marie-Claire Mechin, UMR5165, Faculte de Medecine, 37 Review Article allees Jules Guesde, F-31073 Toulouse cedex, France. Tel.: +33 561145948 fax: +33 561145938 e-mail: A short historyof sweat gland biology mechin(aludear.cnrs.fr K. Wilke, A. Martin, L. Terstegen and S. S. Biel 'Present address: Epithelial Cell Biology (Skin), Cambridge Beiersdorf AG, Hamburg, Germany Research Institute, Lika Shing Centre, Robinson Way, Cambridge CB2 ORE, U.K. Dr Katrin Wilke, Beiersdorf AG, PO Box 550, UnnastraBe 48, D-20245 Hamburg, Germany. Tel.: +49 (0)40 4909 Deimination (or citrullination) is a recently described post- 6436 fax: +49 (0)40 4909 4882 e-mail: translational modification, but its consequences are not yet katrin.wilke@beiersdorf.com well understood. It is catalysed by peptidylarginine deiminases (PADs ). These enzymes transform arginyl The axilla, especially its microflora and axillary sweat residues involved in a peptidyl link into citrullyl residues in glands as well as their secretions, is the main target of a calcium-dependent manner. Several PAD substrates have cosmetic compositions such as deodorants or already been identified like filaggrin and keratins Kl and antiperspirants. There are three types of sweat glands KIO in the epidermis, trichohyalin in hair follicles, but also present in the axillary skin, namely apocrine, eccrine and ubiquitous proteins like histones. PADs act in a large panel apoeccrine sweat glands. Here, we provide an overview of * These abstracts appear as they were originally published. They have not been edited by the Journal of Cosmetic Science. 539