655 Bidirectional Gut-Skin Axis
(86) Thompson KG, Rainer BM, Antonescu C, et al. Comparison of the skin microbiota in acne and rosacea.
Exp Dermatol. 2021 30(10):1375–1380. doi:10.1111/exd.14098
(87) Weiss E, Katta R. Diet and rosacea: the role of dietary change in the management of rosacea. Dermatol
Pract Concept. 2017 7(4):31–37. doi:10.5826/dpc.0704a08
(88) Rebora A, Drago F, Parodi A. May Helicobacter pylori be important for dermatologists? Dermatology.
1995 191(1):6–8. doi:10.1159/000246470
(89) Parodi A, Paolino S, Greco A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness
of its eradication. Clin Gastroenterol Hepatol. 2008 6(7):759–764. doi:10.1016/j.cgh.2008.02.054
(90) Egeberg A, Weinstock LB, Thyssen EP, Gislason GH, Thyssen JP. Rosacea and gastrointestinal disorders:
A population-based cohort study. Br J Dermatol. 2017 176(1):100–106. doi:10.1111/bjd.14930
(91) Nam J-H, Yun Y, Kim H-S, et al. Rosacea and its association with enteral microbiota in Korean females.
Exp Dermatol. 2018 27(1):37–42. doi:10.1111/exd.13398
(92) Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P. Targeting the gut-skin axis—probiotics as new
tools for skin disorder management? Exp Dermatol. 2019 28(11):1210–1218. doi:10.1111/exd.14016
(93) Vargason AM, Anselmo AC. Live biotherapeutic products and probiotics for the skin. Adv Nanobiomed
Res. October 2021 1(12). doi:10.1002/anbr.202100118
(94) FDA. Early Clinical Trials with Live Biotherapeutic Products: Chemistry, Manufacturing, and Control
Information Guidance for Industry, Tech. Rep. Cent. Biol. Eval. Res. 2016:1–17.
(95) Ağagündüz D, Gençer Bingöl F, Çelik E, et al. Recent developments in the probiotics as live biotherapeutic
products (LBPs) as modulators of gut brain axis related neurological conditions. J Transl Med. October
2022 20(1):460. doi:10.1186/s12967-022-03609-y
(96) Rutter JW, Dekker L, Owen KA, Barnes CP. Microbiome engineering: engineered live biotherapeutic
products for treating human disease. Front Bioeng Biotechnol. September 2022 10:1000873. doi:10.3389/
fbioe.2022.1000873
(97) De Almeida CV, Antiga E, Lulli M. Oral and topical probiotics and postbiotics in skincare and
dermatological therapy: A concise review. Microorganisms. May 2023 11(6). doi:10.3390/microorganisms
11061420
(98) Roslan MAM, Omar MN, Sharif NAM, et al. Recent advances in single-cell engineered live biotherapeutic
products research for skin repair and disease treatment. npj Biofilms Microbiomes. December 2023 9(1):95.
doi:10.1038/s41522-023-00463-8
(99) Wang IJ, Wang JY. Children with atopic dermatitis show clinical improvement after Lactobacillus
exposure. Clin Exp Allergy. 2015 45(4):779–787. doi:10.1111/cea.12489
(100) Han Y, Kim B, Ban J, et al. A randomized trial of Lactobacillus plantarum CJLP133 for the treatment
of atopic dermatitis. Pediatr Allergy Immunol. 2012 23(7):667–673. doi:10.1111/pai.12010
(101) Woo S-I, Kim J-Y, Lee Y-J, Kim N-S, Hahn Y-S. Effect of Lactobacillus sakei supplementation in
children with atopic eczema-dermatitis syndrome. Ann Allergy Asthma Immunol. 2010 104(4):343–348.
doi:10.1016/j.anai.2010.01.020
(102) Huang R, Ning H, Shen M, Li J, Zhang J, Chen X. Probiotics for the treatment of atopic dermatitis
in children: A systematic review and meta-analysis of randomized controlled trials. Front Cell Infect
Microbiol. September 2017 7:392. doi:10.3389/fcimb.2017.00392
(103) Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic
disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003 361(9372):1869–1871.
doi:10.1016/S0140-6736(03)13490-3
(104) Navarro-López V, Ramírez-Boscá A, Ramón-Vidal D, et al. Effect of oral administration of a mixture
of probiotic strains on SCORAD index and use of topical steroids in young patients with moderate
atopic dermatitis: A randomized clinical trial. JAMA Dermatol. 2018 154(1):37–43. doi:10.1001/jamader
matol.2017.3647
(105) Kwon M-S, Lim SK, Jang J-Y, et al. Lactobacillus sakei WIKIM30 ameliorates atopic dermatitis-like
skin lesions by inducing regulatory T cells and altering gut microbiota structure in mice. Front Immunol.
August 2018 9:1905. doi:10.3389/fimmu.2018.01905
(86) Thompson KG, Rainer BM, Antonescu C, et al. Comparison of the skin microbiota in acne and rosacea.
Exp Dermatol. 2021 30(10):1375–1380. doi:10.1111/exd.14098
(87) Weiss E, Katta R. Diet and rosacea: the role of dietary change in the management of rosacea. Dermatol
Pract Concept. 2017 7(4):31–37. doi:10.5826/dpc.0704a08
(88) Rebora A, Drago F, Parodi A. May Helicobacter pylori be important for dermatologists? Dermatology.
1995 191(1):6–8. doi:10.1159/000246470
(89) Parodi A, Paolino S, Greco A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness
of its eradication. Clin Gastroenterol Hepatol. 2008 6(7):759–764. doi:10.1016/j.cgh.2008.02.054
(90) Egeberg A, Weinstock LB, Thyssen EP, Gislason GH, Thyssen JP. Rosacea and gastrointestinal disorders:
A population-based cohort study. Br J Dermatol. 2017 176(1):100–106. doi:10.1111/bjd.14930
(91) Nam J-H, Yun Y, Kim H-S, et al. Rosacea and its association with enteral microbiota in Korean females.
Exp Dermatol. 2018 27(1):37–42. doi:10.1111/exd.13398
(92) Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P. Targeting the gut-skin axis—probiotics as new
tools for skin disorder management? Exp Dermatol. 2019 28(11):1210–1218. doi:10.1111/exd.14016
(93) Vargason AM, Anselmo AC. Live biotherapeutic products and probiotics for the skin. Adv Nanobiomed
Res. October 2021 1(12). doi:10.1002/anbr.202100118
(94) FDA. Early Clinical Trials with Live Biotherapeutic Products: Chemistry, Manufacturing, and Control
Information Guidance for Industry, Tech. Rep. Cent. Biol. Eval. Res. 2016:1–17.
(95) Ağagündüz D, Gençer Bingöl F, Çelik E, et al. Recent developments in the probiotics as live biotherapeutic
products (LBPs) as modulators of gut brain axis related neurological conditions. J Transl Med. October
2022 20(1):460. doi:10.1186/s12967-022-03609-y
(96) Rutter JW, Dekker L, Owen KA, Barnes CP. Microbiome engineering: engineered live biotherapeutic
products for treating human disease. Front Bioeng Biotechnol. September 2022 10:1000873. doi:10.3389/
fbioe.2022.1000873
(97) De Almeida CV, Antiga E, Lulli M. Oral and topical probiotics and postbiotics in skincare and
dermatological therapy: A concise review. Microorganisms. May 2023 11(6). doi:10.3390/microorganisms
11061420
(98) Roslan MAM, Omar MN, Sharif NAM, et al. Recent advances in single-cell engineered live biotherapeutic
products research for skin repair and disease treatment. npj Biofilms Microbiomes. December 2023 9(1):95.
doi:10.1038/s41522-023-00463-8
(99) Wang IJ, Wang JY. Children with atopic dermatitis show clinical improvement after Lactobacillus
exposure. Clin Exp Allergy. 2015 45(4):779–787. doi:10.1111/cea.12489
(100) Han Y, Kim B, Ban J, et al. A randomized trial of Lactobacillus plantarum CJLP133 for the treatment
of atopic dermatitis. Pediatr Allergy Immunol. 2012 23(7):667–673. doi:10.1111/pai.12010
(101) Woo S-I, Kim J-Y, Lee Y-J, Kim N-S, Hahn Y-S. Effect of Lactobacillus sakei supplementation in
children with atopic eczema-dermatitis syndrome. Ann Allergy Asthma Immunol. 2010 104(4):343–348.
doi:10.1016/j.anai.2010.01.020
(102) Huang R, Ning H, Shen M, Li J, Zhang J, Chen X. Probiotics for the treatment of atopic dermatitis
in children: A systematic review and meta-analysis of randomized controlled trials. Front Cell Infect
Microbiol. September 2017 7:392. doi:10.3389/fcimb.2017.00392
(103) Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic
disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003 361(9372):1869–1871.
doi:10.1016/S0140-6736(03)13490-3
(104) Navarro-López V, Ramírez-Boscá A, Ramón-Vidal D, et al. Effect of oral administration of a mixture
of probiotic strains on SCORAD index and use of topical steroids in young patients with moderate
atopic dermatitis: A randomized clinical trial. JAMA Dermatol. 2018 154(1):37–43. doi:10.1001/jamader
matol.2017.3647
(105) Kwon M-S, Lim SK, Jang J-Y, et al. Lactobacillus sakei WIKIM30 ameliorates atopic dermatitis-like
skin lesions by inducing regulatory T cells and altering gut microbiota structure in mice. Front Immunol.
August 2018 9:1905. doi:10.3389/fimmu.2018.01905