624 JOURNAL OF COSMETIC SCIENCE
functions. For studies on fibroblast, we concentrated on ECM components that play a more
structural role, particularly in scar remodelling and tissue integrity. pKTSKS increases
corneal layer thickness and hyaluronic acid synthesis helping to reinforce the skin barrier
and moisturizing functions. We observed that collagen-I, collagen -IV, and fibronectin
production in fibroblasts increased in cells treated with pKTSKS. We hypothesized that
pKTSKS contributes to the improvement of acne scars through dual mechanisms: its
structural role in the dermis, enhancing ECM organization and collagen synthesis, and its
barrier-strengthening role in the epidermis, which enhances hydration and improves tissue
resilience. By targeting both the dermal matrix and epidermal hydration, pKTSKS may act
synergistically to accelerate scar healing and restore skin health.
Associated with C. acnes growth limitation, these data could explain the reduction of redness
and inflammatory blemishes and reduction of roughness observed during clinical tests.
Peptides are known to act safely and efficiently on skin cells and are valuable technologies
for cosmetic industry.17–20,30,31 This pentapeptide modulates skin damage induced by C. acnes
through the control of its quorum to consequently reduce adhesion, biofilm formation and
unpleasant effects on skin (scars, blemishes). In vitro investigations have been confirmed via
two clinical studies that measured skin relief imperfections and facial skin microbiome.
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