2005 ANNUAL SCIENTIFIC SEMINAR - - - - Hydrophilic actives inside fflil vesicle Lipophilic actives within bilayer Figure 2. Formation of vesicles from dimethicone PEG-12 copolymers and the proposed actives payload sites. These polymeric vesicles are useful for delivery of actives. To prove the product concept, vitamin A palmitate 479 (VAP) was incorporated into the vesicles formed by the dimethicone PEG-12 copolymer. The vitamin-loaded vesicles were subsequently formulated into model skin care products. Formulation latitude and compatibility with common cosmetic ingredients also were investigated. The Cryo-TEM images in Figure 3 show the sustainability of silicone vesicles in body lotion and moisturizing geJ, as confirmed by the characteristic honeycomb vesicle aggregates found only in this type of vesicles. (A) Figure 3. Cryo-TEM images ofbody lotion (A) and moisturizing gel (B) containing vitamin A palmitate encapsulated within silicone vesicles from dimethicone PEG-12 copolymer. Conclusions: Novel silicone vesicles with distinctive honeycomb morphology have been successfully prepared from (AB)0 dimethicone PEG-12 copolymers. Copolymers of specific dimethicone chain architecture are essential to the formation of bilayers and vesicles, as illustrated in our proposed model. A proof-of-concept study was presented to show that these polymeric silicone vesicles are suitable for delivery of actives in personal care formulations. Vesicle-encapsulated vitamin A palmitate was further incorporated into gels, body lotions and creams. The sustainability of vesicle assemblies in gels and body lotions was shown via cryo-TEM. The stability of entrapped vitamin in vesicles and in formulations at 40 °C was quantified using HPLC. References: I. Lin, S.8., Postiaux, S., Kim, G., "Development of A Novel Silicone-based Vesicle Delivery System," 23nt IFSCC (October 2004, Orlando, FL). 2. Lin, S.B., Stoller, C., Newton, J., Starch M.S. and Postiaux, S. "Silicone Delivery Systems: Opportunities for Controlled Release," in "Advanced Technology Conference 2004" Milan, Italy, April 26-27, 2004. 3. Hill, R.M., He, M., Lin. Z., Davis, H.T., and Scriven, L.E. "Lyotropic Liquid Crystal Phase Behavior of Polymeric Siloxane Surfactants," Langmuir, 9, pp.2789-2798, /993. 4. Hill, R.M., Snow, S.A., US Patents 5,364,633 (Nov. 15, 1994 to Dow Coming) and 5,411,744 (May 2, 1995 to Dow Coming) "Silicone Vesicles and Entrapment."

J. Cosmet. Sci., 56, 481--487 (November/December 2005) AUTHOR INDEX TO VOLUME 56 Abriat, A., Emotional and psychological effects of fragrance in men's skin care (Abstract, IFSCC), 281 Abmtyn, E. S., see DiMuzio, A. M., 356 see Simion, F. A., 427 Abu-Jdayil, B., Rheology of Dead Sea shampoo containing the antidandruff Climbazole (Abstract, IJCS), 152 Agisim, G., The nose knows or working at the "old factory" formulation parameters for nasal delivery systems (2004 Annual Scientific Meeting), 472 Akutsu, T., see Hiwatari, Y., 57 Al-Bawab, A., Evaporation of a model skin lotion with beta-hydroxy acids (Abstract, IJCS), 151 Albiston, L., see Wills, J., 64 Anton, J. M. G., see Cebrian, J., 445 Appa, Y., see Homby, S. B., 282 Asa, T., see Nagai, Y., 205 Askar, N. A., see Syed, A. N., 463 Balaguer, P., see Wiechers, J. W., 209 Baldassari, S., see Villa, 207 Barkat, S., see Abriat, A., 28 l Bastien, P., see Jourdain, R., 153 Beard, B. C., Electron spectroscopy and microscopy applied to chemical and structural analysis of hair, 65: Polymeric delivery systems for hair conditioner actives (2004 Annual Scientific Meeting), 466 Bellantone, R. A., see Mahamongkol, H., 91 Bensafi, M., see Abriat, A., 281 Berardesca, E., see Primavera, G., 207, 334 Berge, C. A., see Bissett, D. L., 60: see Robinson, L. R., 280 Biel, S.S., see Schepky, A.G., 59 Bielfeldt, S., see Scherdin, U., 60 Bissett, D. L., Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin, (Abstract, IJCS), 60: see Robinson, L. R., 280 Blaschke, J. W., Regulatory update on preservatives-Wordwide focus (2005 Annual Scientific Seminar), 364 Bord.at, P., see Guitton, C., 79 Borelli, C., see Otte, N., 445 Boucesein, W., see Eisfeld, W., 211 Bowman, J. P ., Effects of age on human cumulative irritation responses, 213: see Knaggs, H., 60 Bronaugh, R. L. see Haynes, C. T., 376 Buchholz, H., see Walenzyk, T., 280 Burgess, A. N., see Ren, X. J., 282 Butts, M. D., see Yamada, M., 193 Callaghan, T., An examination of non-invasive imaging techniques in the analysis and review of cellulite, 379 Calle, J., see Jimenez, J., 212 Cambria, F. M., see Beard, B. C., 65 Cantwell, M. Y., see DiMuzio, A. M., 356 Carlotti, M. E., see Sapino, S., 227 Carola, C., see Walenzyk, T., 280 Carson, J ., A microscopic look at emulsions (2004 Annual Scientific Meeting), 450 Cebrian, J., New anti-RNS and -RCS products for cosmetic treatment (Abstract, lJCS), 445 Chang, M., see Kang, N., 281 Chaudhuri, R. K., Skin lightening and anti-aging ingredients-How are they interlinked? {2005 Annual Scientific Seminar), 354 Chen, H., Determination of phthalate esters in cosmetics by gas chromatography with flame ionization detection and mass spectrometric detection (Abstract, IJCS), 334 Chesne, C., see Wiechers, J. W., 209 Chin, C., see Wang, L-H., 183 Cho, I., see Kim, Y-D., Cho, W., see Kang, N., 281 Choi, M. J ., Elastic vesicles as topical/ trartsdermal drug delivery systems (Abstract, IJCS), 334 Choi, S., see Kang, N., 281 Choi, Y., see Gao, T., 374 481