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J. Cosmet. Sci.) 56, 445-446 (November/December 2005) Abstracts International Journal of Cosmetic Science Vol. 27, No. 5, 2005* Nicotinamide � biologic actions of an emerging cosmetic ingredient N. Otte, C. Borelli and H. C. Korting Department of Dermatology and Allergology, University of Munich, Munich, Germany Nicotinamide, the water-soluble amide of nicotinic acid, is a component of the two most important coenzymes - nicotinarnide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation­ reduction reactions in mammalian biological systems. Nicotinamide essentially acts as an antioxidant. Most effects are exerted via poly-adenosine diphosphate­ ribose polymerase inhibition. Thus nicotinarnide increasingly gains interest in the prevention and treatment of several skin diseases. It is well established in the systemic therapy of pellagra, a deficiency disease linked to nicotinic acid, but with respect to topical use there is still a need for further evidence with respect to its manifold potential uses. Currently, its local use is established in the care of acne-prone skin. New anti-RNS and -RCS products for cosmetic treatment J. Cebrian*, A Messeguer, R. M. Facino and J. Ma. Garcia Anton* *Research and Development Department, LIPOTEC, SA, C/lsaac Peral, 17, 08850 Gava'. Barcelona, Spain, Bioorganic Chemistry Department, IIQAB-CSIC and lstituto Chimico Farmaceutico Tossicologico, University of Milan, Milan, Italy Oxidants and :free radicals are known to be a very important factor in skin aging, taking an active part in lipidic peroxidation, breakage of proteins and DNA, etc. The most well-known are reactive oxygen species (ROS), for example, superoxide radical anion, or more commonly called, superoxide (0 _ 2 ), hydroxyl radical (OH•) or hydrogen peroxide (H2O2). Both :free radicals and other oxidants can be generated by metabolic activity within the cell and by other environmental challenges. In addition, other dangerous species are known such as reactive nitrogen species (RNS) and reactive carbonyl species (RCS). Some of the most important RNS are perox:ynitrite (ONOO)), nitrogen dioxide radical (•NO2) and the nitronium ion (NOp2). For RCS, some of the most important are 4- hydrox:ynonenal (HNE), actolein (ACR), malondialdehyde (MDA) or glyoxal (GXL). Both compounds (RNS and RCS) are thought to play an important role in many diseases and in skin aging, for example, collagen cross-linking, DNA damage, protein tyrosine nitration, etc. This work investigates two new specific chemicals: Lipochroman-6 - an anti-RNS which shows good results in inhibiting the nitration of tyrosine by peroxynitrite, and Aldenine - a tripeptide anti-RCS which protects cells :from reactive carbonyl compounds such as HNE or ACR it also shows the ability to prevent glycation of proteins, specifically by superoxide dismutase (SOD). Unveiling the molecular basis of intrinsic skin agingl 0. Holtkotter*, K. Schlotmann*, H. Hofheinz, R. R. Olbrisch and D. Petersohn* *Henkel KGaA. HenkelstraBe 67, 40 191 Dusseldorf, Germany and Clinic for Plastic Surgery, Florence­ Nightingale-Hospital, KreuzbergstraBe 79, 40 489 Dusseldorf, Germany The process of skin aging is a combination of an extrinsic and intrinsic aspect, and knowing the molecular changes underlying both is a prerequisite to being able to effectively counter it. However, despite its * These abstracts appear as they were originally published. They have not been edited by the Journal of Cosmetic Science. 445