374 JOURNAL OF COSMETIC SCIENCE
leisure, recreation, fitness, self-confidence, personal pleasure, and vitality. Questionnaire-
based QoL type instruments have demonstrated that subjects with sensitive skin score worse
in satisfaction with appearance, daily life, and sense of well-being. Subjects with SSS had
significantly worse scores for sleep disorders compared to subjects without sensitive skin.
Becoming aware of both the vicious cycle of biopsychosocial impacts and how it can impact
individuals with SSS can help both the practitioner and consumer to understand, manage,
and develop more appropriate approaches and programs (i.e., treatments, therapies, and so
forth) to drive a more holistic and sustainable QoL impact for SSS consumers. We reiterate
the call to consider SSS as an integrative multiphenomena condition to not only drive more
holistic understanding of the syndrome, but also continue to pursue solutions (i.e., skin
ingredients/products) that would inclusively and collectively impact skin/body/mind state
of SSS sufferers.66
REFERENCES
(1) Farage MA. Understanding the sensitive skin subject to achieve a more holistic diagnosis. Cosmetics.
2021 8(3):81. doi:10.3390/cosmetics8030081
(2) Bataille A, Le Gall-Ianotto CL, Genin E, Misery L. Sensitive skin: lessons from transcriptomic studies.
Front Med (Lausanne). 2019 6:115. doi:10.3389/fmed.2019.00115
(3) Misery L, Ständer S, Szepietowski JC, et al. Definition of sensitive skin: an expert position paper from
the special interest group on sensitive skin of the international forum for the study of itch. Acta Derm
Venereol. 2017 97(1):4-6. doi:10.2340/00015555-2397
(4) Berardesca E, Farage M, Maibach H. Sensitive skin: an overview. Int J Cosmet Sci. 2013 35(1):2-8.
doi:10.1111/j.1468-2494.2012.00754.x
(5) Farage MA. The prevalence of sensitive skin. Front Med (Lausanne).2019 6:98.doi:10.3389/fmed.2019.00098
(6) Chen W, Dai R, Li L. The prevalence of self-declared sensitive skin: A systematic review and meta-
analysis. J Eur Acad Dermatol Venereol. 2020 34(8):1779-1788. doi:10.1111/jdv.16166
(7) Misery L, Jourdan E, Abadie S, et al. Development and validation of a new tool to assess the Burden of
Sensitive Skin (BoSS). J Eur Acad Dermatol Venereol. 2018 32(12):2217-2223. doi:10.1111/jdv.15186
(8) Cho HJ, Chung BY, Lee HB, Kim HO, Park CW, Lee CH. Quantitative study of stratum corneum
ceramides contents in patients with sensitive skin. J Dermatol. 2012 39(3):295-300. doi:10.1111/​
j.1346-8138.2011.01406.x
(9) Cua AB, Wilhelm KP, Maibach HI. Cutaneous sodium lauryl sulphate irritation potential: age and
regional variability. Br J Dermatol. 1990 123(5):607-613. doi:10.1111/j.1365-2133.1990.tb01477.x
(10) Pons-Guiraud A. Sensitive skin: A complex and multifactorial syndrome. J Cosmet Dermatol.
2004 3(3):145-148. doi:10.1111/j.1473-2130.2004.00082.x
(11) Misery L, Weisshaar E, Brenaut E, et al. Pathophysiology and management of sensitive skin: position
paper from the special interest group on sensitive skin of the International Forum for the Study of Itch
(IFSI). J Eur Acad Dermatol Venereol. 2020 34(2):222-229. doi:10.1111/jdv.16000
(12) Roussaki-Schulze AV, Zafiriou E, Nikoulis D, Klimi E, Rallis E, Zintzaras E. Objective biophysical
findings in patients with sensitive skin. Drugs Exp Clin Res. 2005 31(suppl):17-24.
(13) Misery L, Loser K, Ständer S. Sensitive skin. J Eur Acad Dermatol Venereol. 2016 30(suppl 1):2-8.
doi:10.1111/jdv.13532
(14) Buhé V, Vié K, Guéré C, et al. Pathophysiological study of sensitive skin. Acta Derm Venereol.
2016 96(3):314-318. doi:10.2340/00015555-2235
(15) Ehnis-Pérez A, Torres-Álvarez B, Cortés-García D, Hernández-Blanco D, Fuentes-Ahumada C,
Castanedo-Cázares JP. Relationship between transient receptor potential vanilloid-1 expression and the
intensity of sensitive skin symptoms. J Cosmet Dermatol. 2016 15(3):231-237. doi:10.1111/jocd.12204

375 Sensitive Skin Syndrome
(16) Kueper T, Krohn M, Haustedt LO, Hatt H, Schmaus G, Vielhaber G. Inhibition of TRPV1 for the
treatment of sensitive skin. Exp Dermatol. 2010 19(11):980-986. doi:10.1111/j.1600-0625.2010.01122.x
(17) Mikkelsen CS, Holmgren HR, Kjellman P, et al. Rosacea: A clinical review. Dermatol Reports.
2016 8(1):6387. doi:10.4081/dr.2016.6387
(18) Chang ALS, Raber I, Xu J, et al. Assessment of the genetic basis of rosacea by genome-wide association
study. J Invest Dermatol. 2015 135(6):1548-1555. doi:10.1038/jid.2015.53
(19) Kim YR, Cheon HI, Misery L, Taieb C, Lee YW. Sensitive skin in Korean population: an epidemiological
approach. Skin Res Technol. 2018 24(2):229-234. doi:10.1111/srt.12418
(20) Brenaut E, Misery L, Taieb C. Sensitive skin in the Indian population: an epidemiological approach.
Front Med (Lausanne). 2019 6:29. doi:10.3389/fmed.2019.00029
(21) Wang X-Y, Liu Y-Y, Liu Y-X, et al. A predictive model for differential diagnosis between rosacea and
sensitive skin: A cross-sectional study. Chin Med J (Engl). 2020 133(17):2132-2134. doi:10.1097/CM9.000​
0000000001001
(22) Willis CM, Shaw S, De Lacharrière O, et al. Sensitive skin: an epidemiological study. Br J Dermatol.
2001 145(2):258-263. doi:10.1046/j.1365-2133.2001.04343.x
(23) Misery L, Jourdan E, Huet F, et al. Sensitive skin in France: A study on prevalence, relationship with age
and skin type and impact on quality of life. J Eur Acad Dermatol Venereol. 2018 32(5):791-795. doi:10.1111/
jdv.14837
(24) Farage MA, Bowtell P, Katsarou A. Self-diagnosed sensitive skin in women with clinically diagnosed
atopic dermatitis. Clin Med Dermatol. 2008 2:21-28.
(25) Farage MA, Jiang Y, Tiesman JP, Fontanillas P, Osborne R. Genome-wide association study identifies
loci associated with sensitive skin. Cosmetics. 2020 7(2):49. doi:10.3390/cosmetics7020049
(26) Misery L, Cochener B, Brenaut E, Séité S, Taieb C. Association of sensitive skin with sensitive corneas
and sensitive eyelids. J Eur Acad Dermatol Venereol. 2019 33(7):1358-1362. doi:10.1111/jdv.15595
(27) Misery L, Duboc H, Coffin B, Brenaut E, Huet F, Taieb C. Association between two painful and poorly
understood conditions: irritable bowel and sensitive skin syndromes. Eur J Pain. 2019 23(1):160-166.
doi:10.1002/ejp.1296
(28) Huet F, Misery L. Sensitive skin is a neuropathic disorder. Exp Dermatol. 2019 28(12):1470-1473. doi:10.1111/​
exd.13991
(29) Farage MA. Perceptions of sensitive skin with age. In: Farage MA, Miller KW, Maibach HI, eds. Textbook
of Aging Skin. 2nd ed. Springer 2017.
(30) Robinson MK. Population differences in acute skin irritation responses. Race, sex, age, sensitive skin and
repeat subject comparisons. Contact Dermatitis.2002 46(2):86-93.doi:10.1034/j.1600-0536.2002.460205.x
(31) Lejman E, Stoudemayer T, Grove G, Kligman AM. Age differences in poison ivy dermatitis. Contact
Dermatitis. 1984 11(3):163-167. doi:10.1111/j.1600-0536.1984.tb00964.x
(32) Grove GL, Duncan S, Kligman AM. Effect of ageing on the blistering of human skin with ammonium
hydroxide. Br J Dermatol. 1982 107(4):393-400. doi:10.1111/j.1365-2133.1982.tb00382.x
(33) Misery L, Sibaud V, Merial-Kieny C, Taieb C. Sensitive skin in the American population: prevalence, clinical
data, and role of the dermatologist. Int J Dermatol. 2011 50(8):961-967. doi:10.1111/j.1365-4632.2011​.04884.x
(34) Xiao X, Qiao L, Ye R, Zuo F. Nationwide survey and identification of potential stress factor in sensitive
skin of Chinese women. Clin Cosmet Investig Dermatol. 2020 13:867-874. doi:10.2147/CCID.S284359
(35) Farage MA. Does sensitive skin differ between men and women? Cutan Ocul Toxicol. 2010 29(3):153-163.
doi:10.3109/15569521003774990
(36) Farage MA, Mandl CP, Berardesca E, Maibach HI. Sensitive skin in China. J Cosmet Dermatol Sci Appl.
2012 02(3):184-195. doi:10.4236/jcdsa.2012.23035
(37) Farage MA. Sensitive skin in the genital area. Front Med (Lausanne). 2019 6:96. doi:10.3389/fmed.2019​ ​
00096
(38) Farage MA, Neill S, MacLean AB. Physiological changes associated with the menstrual cycle: a review.
Obstet Gynecol Surv. 2009 64(1):58-72. doi:10.1097/OGX.0b013e3181932a37