AGE RELATED BALDNESS Table VI Increase in Hair Per Unit Area of Scalp: Men 491 Mean Number of Hairs/cm 2a Increase as Signed Subject Control Period Treatment Period Difference Per Cent of Control Rank JP 132 139 7 5 2 GT 169 171 2 1 1 RB 132 157 25 19 12 EF 140 154 14 10 7.5 JHo 107 125 18 17 11 FE 249 320 71 7 4.5 JW 99 110 11 11 9 RD 141 153 12 9 6 WL-C 66 70 4 6 3 RP 113 147 34 30 13 JM 109 120 11 10 7.5 GW 159 172 12 7 4.5 JHa 141 162 21 15 10 RD • b b b (0)b TB b b b b (0)b n = 15 •Ri+ = 91 ERA- = 0 Wilcoxon Signed Rank Test: P 0.001 aEach value represents the mean of 2 determinations, where possible on the first 2 visits of the control period and the last 2 visits of the treatment period. bThese 2 patients dropped out after completing the control period, but before completing the treatment pe- riod. They were arbitrarily assigned the most unfavorable results on the table. Table VII Increase in Hair Per Unit Area of Scalp: Women Mean Numbers of Hairs/Cm 2 Increase as Signed Subject Control Period Treatment Period Difference Per Cent of Control Rank PH 89 129 30 33 9 ER 207 250 43 20 6 PM 148 194 46 31 8 LS 207 207 0 0 KH 81 100 19 23 7 MM 186 281 95 51 10 KA 114 129 15 13 1 CJ 221 189 -32 -14 •2 BEyb b b b (- 15) b -3 BS • b • • (--16) b -4 EM b b b b (-- 17) b -- 5 n=10 ERi+ = 41 ERi- = 14 Wilcoxon Signed Rank Test: 0.081 p 0.097 •Each value represents the mean of 6 determinations, 3 from each of 2 visits during control, and the same during treatment. •These 3 patients dropped out after completing the control period, but before completing the treatment pe- riod. They were arbitrarily assigned the most unfavorable results on the table.

492 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS tion of dormant, possibly empty, telogen follicles to re-enter anagen could have increased the number of hairs counted per unit area. Tables VI and VII present evi- dence for an increase in the density of hair in men, while showing a somewhat weaker trend toward improvement in women. Closer inspection of Table VI, however, shows that such increases were quantitatively slight, all but 1 being less than 20 per cent, and lacked biological if not statistical significance. ARB is accompanied by gradual shortening in the anagen, or growing phase of each hair and lengthening in the telogen or dormant phase. In areas destined to become bald, the resultant hair also shrinks in diameter following each cycle until only a slender stub remains (28-29). We wondered whether the treatment regimen might influence the physiologic cues which govern these phases of growth, specifically whether we might find a greater proportion of anagen hairs in the scalp following treatment the only method readily available for detecting such changes in the manual method of counting the total as well as number of telogen roots in a plucked sample. Table VIII shows that we were unable to detect significant changes during the treatment period in male subjects. Similar results were observed in women (data not shown). Table VIII Changes in Percentage of Hair Roots in Telogen Stage: Men Percentage of Plucked Hair Roots in Telogen a Signed Subject Control Period Treatment Period Difference b Rank RW 29 20 9 10 JP 7 8 -1 -1.5 MG 26 8 16 14 EG 17 16 1 1.5 GT 18 10 8 8.5 RB 16 4 12 12 EF 33 12 21 16 JHo 50 9 41 20 FE 25 23 2 3 JW 8 41 -33 -17 RD 24 24 0 -- WL-C 9 19 - 10 - 11 RP 12 19 -7 -6.5 HG 4 23 -19 -15 JM 26 18 8 8.5 GW 22 29 -7 -6.5 JHa 10 25 -15 -13 DC 20 17 3 4.5 DG 42 48 - 3 -4.5 RD •' 11 •' (-34f -18 TB" 8 c (-35) •' -19 n=21 ZRi+ = 98 •Ri- = 112 Wilcoxon Signed Rank Test: not significant aEach value represents the mean of at least 3 determinations. bSince the values in the difference column represent differences between percentages, they have not been further normalized. CThese 2 patients dropped out after completing the control period, but before completing the treatment pe- riod. They were arbitrarily assigned the most unfavorable results on the table.