382 JOURNAL OF COSMETIC SCIENCE Figure 5. Haze values of formulations prepared with polymers at 0.2 wt % (left figure) or 0.4 wt % (right figure) and SLES-2 mol or SLES-3 mol at 8 wt % at dilution l. Figure 6. Haze values of formulations prepared with polymers at 0.2 wt % (left figure) or 0.4 wt % (right figure) and SLES-2 mol or SLES-3 mol at 10 wt % at dilution 1. high level of CAPB (3.75 wt % or 5 wt %) and low level of "surfactant 3" (0 or 1.25 wt % ) showed higher haze than the corresponding formulations with low level of CAPB and high level of "surfactant 3". The level of SoftCAT™ SL polymers also showed a moderate effect on haze, with higher polymer level resulting in higher haze. However, the type of a polymer had a negligible effect on haze, suggesting that small differences in the level of hydrophobic substitution are not critical in formation of coacervates. Selected formulations from this study were also prepared using a standard (bench-top) method. Water was added to formulations that were prepared at dilution 1 to give dilutions 6 and 8. Haze data for those samples were essentially identical (within the limits of experimental error) to haze values of formulations from the high-throughput study. This result further confirms the applicability of high throughput workflow for study of coacervate formation in shampoo systems. CONCLUSIONS In this study of coacervate formation in shampoo systems, a high throughput workflow was developed for the preparation of formulations with different types and levels of cationic cellulosic polymers and surfactants, and for measurement of their haze values. Our results provide information on the effect of formulation components on the haze

2006 TRI/PRINCETON CONFERENCE 383 index. Higher level of SoftCAT™ SL polymers (0.40 wt%) resulted in higher haze than the lower level (0.20 wt % ), while the level of hydrophobic substitution had only a minor effect on haze. Among the surfactants evaluated, SLES showed major effect on the haze index. SLES-3 mol showed higher haze than SLES-2 mol, and lower levels of SLES (6 wt % and 8 wt %) showed higher haze than 10 wt % SLES. The level of other surfactants also showed effect on the haze index. Formulations with high levels of CAPB (3.75 wt % or 5 wt %) and low level of "surfactant 3" (0 wt % or 1.25 wt %) showed higher haze than the corresponding formulations with low level of CAPB and high level of "surfactant 3". Haze data from this high throughput study showed good correlation with samples that were prepared using a standard (bench-top) method. This study illustrates that high throughput workflow is a valuable tool for study of shampoo systems. REFERENCES (1) R. Y. Lochhead, "Shampoos," in The Chemistry and Manufacture of Cosmetics, 3rd Ed., M. I. Schlossman, Ed. (Allured Publishing Corporation, Carol Stream, IL, 2002), Vol 2, pp. 277-326. (2) E. D. Goddard, "Polymer/Surfactant Interaction in Applied Systems," in Principles of Polymer Science and Technology in Cosmetics and Personal Care, E. D. Goddard and J. V. Grubber, Eds. (Marcel Dekker, New York, 1999), p 181. (3) W. Li and S. I. P. Jordan, Cationic cellulosic polymers with multifunctional and outstanding perfor- mance for personal care, Cosmet. Toilet. Manufact. Worldwide, 1-4 (2003). (4) T. V. Drovetskaya, R. I. Kreeger, J. L. Amos, C. B. Davis, and S. Zhou, Effects of low-level hydro- phobic substitution on conditioning properties of cationic cellulosic polymers in shampoo systems,]. Cosmet. Sci., 55 (Suppl.), S195-S205 (2004).